Cellular Microarray: Difference between revisions
Content deleted Content added
Copyediting the lead. Page link to multiplex (assay). |
redirecting to proper capitalization |
||
| Line 1: | Line 1: | ||
#REDIRECT [[Cellular microarray]] |
|||
A '''cellular microarray''', is a [[laboratory]] tool that allows for the [[multiplex (assay)|multiplex]] interrogation of living [[cell (biology)|cells]] on the surface of a solid support. The support, sometimes called a "chip", is spotted with varying materials, such as [[antibodies]], [[proteins]], or [[lipids]], which can interact with the cells, leading to their capture on specific spots. Combinations of different materials can be spotted in a given area, allowing not only cellular capture, when a specific interaction exists, but also the triggering of a cellular response, change in [[phenotype]], or detection of a response from the cell, such as a specific [[secretion|secreted]] factor. An example of cellular microarrays are [[PMHC Cellular Microarrays]]. |
|||
Cellular microarrays were developed by Daniel Chen, Yoav Soen, Dan Kraft, Patrick Brown and Mark Davis at [[Stanford University Medical Center]]. |
|||
==References== |
|||
Chen DS, Davis MM (2006) Molecular and functional analysis using live cell microarrays. Curr Opin Chem Biol 10:28-34 |
|||
Chen DS, Soen Y, Stuge TB, Lee PP, Weber JS, Brown PO, Davis MM (2005) Marked Differences in Human Melanoma Antigen-Specific T Cell Responsiveness after Vaccination Using a Functional Microarray. PLoS Med 2: 10: e265 (http://medicine.plosjournals.org/perlserv/?request=get-document&doi=10.1371%2Fjournal.pmed.0020265) |
|||
Soen Y., Chen D. S., Kraft D. L., Davis M. M. and Brown P.O. (2003) Detection and characterization of cellular immune responses using peptide-MHC microarrays. PLoS Biol. 1: E65 (http://biology.plosjournals.org/perlserv/?request=get-document&doi=10.1371/journal.pbio.0000065) |
|||
Chen DS, Davis MM (2005) Cellular immunotherapy: Antigen recognition is just the beginning. Springer Semin Immunopathol 27:119–127 |
|||
Chen DS, Soen Y, Davis MM, Brown PO (2004) Functional and molecular profiling of heterogeneous tumor samples using a novel cellular microarray. J Clin Oncol 22:9507 (http://meeting.jco.org/cgi/content/abstract/22/14_suppl/9507) |
|||
Soen Y, Chen DS, Stuge TB, Weber JS, Lee PP, et al. (2004) A novel cellular microarray identifies functional deficiences in tumor-specific T cell responses. J Clin Oncol 22:2510 |
|||
[[Category: Biotechnology]] |
|||
Revision as of 04:44, 26 August 2009
Redirect to: