Maltese Cross may refer to:
- The Maltese Cross, a symbol of the Christian warrior since the First Crusade.
- The flower Maltese Cross (Lychins chalcedonica), a flowering plant in the family Caryophyllaceae.
- The Maltese Cross mechanism, so-named because one of the wheels has a form reminiscent of a Maltese Cross.
- The plant Silene chalcedonica, commonly known as Maltese cross.