Well-known alumni, living and deceased, of Washington University in St. Louis include:
Arts and literature
- Charles Eames, designer, architect, filmmaker
- Bernard Fuchs (MFA 1954), painter and illustrator
- John Gardner, novelist
- Henry Hampton (AB 1961), filmmaker; producer of PBS documentary "Eyes on the Prize"
- A.E. Hotchner (AB 1940, JD 1940), biographer and novelist (Papa Hemingway, King of the Hill)
- Fannie Hurst (1909), writer and social activist
- Josephine Winslow Johnson, Pulitzer Prize-winning author
- Edward Shepherd Mead (AB 1936), playwright ("How To Succeed in Business Without Really Trying")
- David Merrick (AB 1934), Broadway producer
- Oliver Nelson (student 1954-7), jazz musician and composer
- J.D. Parran (MA 1971), jazz musician
- Harold Ramis (AB 1966), film actor, writer and director
- Eugene B. Redmond (MA 1966), poet, critic, civil-rights activist
- Peter Sarsgaard (BA 1995), actor
- Lauren Weinstein (BA 1998), cartoonist
- Mary Wickes (AB 1930), stage and film actress
- Tennessee Williams (student 1936-37), playwright
- Olly Wilson (BA 1959), composer
- Anita Diamant, novelist
Architecture and design
- Hugh Ferriss (B.Arch 1911, M.Arch 1928), architect
- George Hellmuth (BArch 1928, MArch 1931), architect; cofounder of Hellmuth, Obata & Kassabaum
- George Kassabaum (B.Arch 1947), architect; former president of American Institute of Architects; cofounder of Hellmuth, Obata & Kassabaum
- Gyo Obata (BArch 1945), architect; cofounder and chairman of Hellmuth, Obata & Kassabaum
- Carolyne Roehm (BFA 1973), fashion designer
Business
- John Dubinsky (AB 1965, MBA 1967), former CEO of Mark Twain Bancshares
- Sam Fox (BSBA 1951), founder, chairman, CEO, and owner of Harbour Group LTD
- Don Frahm (BSBA 1953), retired chairman and CEO of the Hartford Insurance Group
- Earle Harbison (AB 1948), former president and COO of Monsanto
- Jeff Lebesch (BS 1979), Co-founder, New Belgium Brewing Company
- Stanley Lopata (AB 1935), founder and former chairman of Carboline
- John F. McDonnell (1967), retired chairman and CEO of McDonnell Douglas
- W. Patrick McGinnis (MBA 1972), president and CEO of Nestle Purina Petcare Company
- William Shaw (MBA 1972), president and COO of Marriott International Inc.
- Louis B. Susman (JD 1962), vice chairman of Citigroup Global Markets
- William G. Tragos (AB 1956), former chairman and CEO of TBWA Advertising, Inc.
- Arnold Zetcher (BSBA 1962), chairman, president & CEO of Talbot's
- George Zimmer (BA 1970), founder of Men's Wearhouse
Education and academics
- Raelynn Hillhouse (BA), novelist, political scientist
- Joyce Ladner (MA 1966, PhD 1968), sociologist and activist
- Max Lerner (MA 1925), intellectual and author
- Walter Massey (MA 1966, PhD 1966), president of Morehouse College
- H. Richard Niebuhr (MA 1917), theologian
- Charles Van Ravenswaay (BA 1933, MA 1934), historian
- Abram L. Sachar (AB 1920, MA 1920), founding president of Brandeis University
- Barry Spizer (BS 1977), Past President of The CCIM Institute of the National Association of Realtors
Journalism and media
- Ken Cooper (AB 1977), Pulitzer Prize-winning journalist; national editor of the Boston Globe
- Lynne "Angel" Cooper Harvey (AB and MA), producer of Paul Harvey News
- Michael Isikoff (1974), journalist
- Condé Nast (LLB 1897), publisher of Vogue
- Mike Peters (BFA 1965), Pulitzer Prize-winning editorial cartoonist; creator of "Mother Goose and Grimm"
Politics, law, and government
- Clark M. Clifford (LLB 1928), U.S. Secretary of Defense, 1968-69; former presidential advisor
- Phoebe Couzins (LLB 1871), first woman U.S. marshal; leader in the women's suffrage movement
- Alan J. Dixon (LLB 1949), U.S. Senator from Illinois, 1981-93
- David R. Francis (AB 1870), St. Louis mayor 1885-89; Missouri governor 1889-93; U.S. Secretary of Interior 1896-97; U.S. Ambassador to Russia
- Moses W. Harrison II (JD 1958), chief justice of the Illinois Supreme Court
- Chic Hecht (BS 1949), U.S. Senator from Nevada, 1983-89
- Phyllis Schlafly (BA 1944, JD 1978), author, political activist
- Jim Talent (BA 1978), U.S. Senator from Missouri, 2003-present
- Raymond Tucker (BS 1920), mayor of St. Louis, 1953-1965
- William H. Webster (JD 1949), former director of the CIA and the FBI
Science, engineering, and medicine
- Lee Harrison III (BFA 1952, BS 1959), engineer; Emmy winner for invention of computer animation
- Julian Hill (BS 1924), chemist; co-inventor of nylon
- Daniel Nathans (1954), Nobel laureate in medicine
- Sol Spiegelman (PhD 1944), molecular biologist
- Corinne Bott-Silverman (AB 1975), the first female cardiologist at the Cleveland Clinic
- Harvey N. Silverman (AB 1974, DMD 1978), inventor of Perfect Smile, Rapid White, and White Light tooth whiteners. A pioneer in the field of cosmetic dentistry.
Sports
- Jim Conzelman (BS 1917), professional athlete; enshrined in three Halls of Fame, including pro-football's hall
- Justin M. Forer, (MBA 2001), Founder of Topes Franchise and J.Michael's Steakhouses franchise
- George Herbert Walker, (LLB 1897), founder of Walker Cup in golf; grandfather and great-grandfather of Presidents George H.W. Bush and George W. Bush, respectively
- Charley Winner, longtime coach in the National Football League