ID-4708
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| This article, ID-4708, has recently been created via the Articles for creation process. Please check to see if the reviewer has accidentally left this template after accepting the draft and take appropriate action as necessary.
Reviewer tools: Inform author |
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| CAS Number | |
| PubChem CID | |
| ChemSpider | |
| CompTox Dashboard (EPA) | |
| Chemical and physical data | |
| Formula | C22H24F4N2O2 |
| Molar mass | 424.440 g·mol−1 |
| 3D model (JSmol) | |
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ID-4703 is a butyrophenone neuroleptic agent. It has the same structure as for trifluperidol but differs by the incorporation of an aniline amino group into the butyrophenone sidechain.
Whereas trifluperidol is a Belgian drug developed at Janssen Pharmaceuticals, ID-4708 was developed by a Japanese company called Sumitomo Chemical in the 1970’s.
ID-4708 when given at low doses reduced ambulation, while at higher doses defecation was inhibited.[1]
Synthesis
The chemical synthesis of ID-4708 was reported:[2][3]
- 2-Acetylbutyrolactone [517-23-7] (1)
- 4-Fluoro-2-nitrobenzoic acid [394-01-4] (2)
- 4-Fluoro-2-nitrobenzoyl chloride [57750-82-0] (3)
- 3-(4-Fluoro-2-nitrobenzoyl)oxolan-2-one [62513-47-7] (4)
- 4-Bromo-1-(4-fluoro-2-nitrophenyl)butan-1-one [62513-48-8] (5)
- 2-(3-Bromopropyl)-2-(4-fluoro-2-nitrophenyl)-1,3-dioxolane [62513-50-2] (6)
- 4-hydroxy-4-(3-trifluoromethylphenyl)piperidine [2249-28-7] (7)
- PC86735492 (8)
- PC70620175 (9)
References
- ^ Honma T, Kitagawa S. [Effects of minor tranquilizers and neuroleptics on open-field behavior in rats (author's transl)]. Nihon Yakurigaku Zasshi. 1977 Apr;73(3):337-45. Japanese. doi: 10.1254/fpj.73.337. PMID: 21127.
- ^ Honma T, Sasajima K, Ono K, Kitagawa S, Inaba S, Yamamoto H. Synthesis and preliminary pharmacology of a novel butyrophenone derivative, ID-4708. Arzneimittelforschung. 1974 Sep;24(9):1248-56. doi: 10.1002/chin.197451331. PMID: 4479786.
- ^ Kikuo Sasajima, et al. US4075346 (1978 to Sumitomo Chemical Co Ltd).