2β-Propanoyl-3β-(4-tolyl)-tropane
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| CompTox Dashboard (EPA) | |
| Chemical and physical data | |
| Formula | C18H25NO |
| Molar mass | 271.396 g·mol−1 |
2β-Propanoyl-3β-(4-tolyl)-tropane also known as WF-11 or PTT is a cocaine analogue 20 times more potent than cocaine at binding to the dopamine transporter with increased selectivity for the norepinephrine transporters. It also shows marked increase in metabolic stability. In contrast to the findings of cocaine effects, WF-11 has been shown to produce a uniform downregulation of TH protein and activity gene expression with a regimen of use. [1]
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References
- ^ Willard M. Freeman, George J. Yohrling, James B. Daunais, Lynda Gioia, Stephanie L. Hart, Linda J. Porrino, Huw M. L. Davies and Kent E. Vran (2000). "ScienceDirect - Drug and Alcohol Dependence : A cocaine analog, 2β-propanoyl-3β-(4-tolyl)-tropane (PTT), reduces tyrosine hydroxylase in the mesolimbic dopamine pathway". Drug and Alcohol Dependence. 61 (1): 15–21. doi:10.1016/S0376-8716(00)00119-8. Retrieved 2008-01-11.
{{cite journal}}: CS1 maint: multiple names: authors list (link)
See also