U.S. Route 66 Business (St. Louis, Missouri)

Business US 66 in the St. Louis, Missouri area was actually one of two business routes in the entire metro St. Louis area. A separate Business US 66 existed in the East St. Louis, Illinois area. In 1939, US 66 was routed over the Chain of Rocks Bridge to have the route bypass the city. Non-bannered 66 continued west down, roughly, Interstate 270 to Lindbergh Boulevard, then south to rejoin the original alingment down Watson Road. The business route turned south on Riverview, Broadway, Florissant Ave, Tucker Boulevard (then 12th Street), then southwest on Gravois Road, then west-southwest on Chippewa Street (which becomes Watson Road in the suburbs). The road was originally designated "City" 66, but in 1960 it became "Business" 66, a trend seen on other city routes across the country. The East St. Louis Business 66 connected with the St. Louis Business 66 at the MacArthur Bridge connnection with Gravois Road. By 1969, Business 66 returned (via the East St. Louis route) to being non-bannered US 66.

Currently, Riverview, Broadway, Florissant, and Tucker are now city streets. Gravois Road is Missouri State Highway 30, and Chippewa Street and Gravois Roads are now Missouri State Highway 366.