Mitragynine pseudoindoxyl
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| Names | |
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| IUPAC name
(E)-methyl 2-((1'S,6'S,7'S,8a'S)-6'-ethyl-4-methoxy-3-oxo-3',5',6',7',8',8a'-hexahydro-2'H-spiro[indoline-2,1'-indolizin]-7'-yl)-3-methoxyacrylate
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| Other names
spiro[2H-indole-2,1'(5'H)-indolizine]-7'-acetic acid, 6'-ethyl-1,2',3,3',6',7',8',8'a-octahydro-4-methoxy-α-(methoxymethylene)-3-oxo-, methyl ester, (αE,2S,6'S,7'S,8'aS)
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| Identifiers | |
3D model (JSmol)
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| ChemSpider | |
CompTox Dashboard (EPA)
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| Properties | |
| C23H30N2O5 | |
| Molar mass | 414.49 |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Mitragynine pseudoindoxyl is an indole alkaloid present in the the plant Mitragyna speciosa, commonly known as Kratom.[1]
Pharmacology
Mitragynine pseudoindoxyl itself acts primarily via mu and delta opioid receptors, being more potent than morphine and about as potent as enkephalin. [2][3]
See also
References
- ^ Jansen KL, Prast CJ (1988). "Ethnopharmacology of kratom and the Mitragyna alkaloids". J Ethnopharmacol. 23 (1): 115–9. doi:10.1016/0378-8741(88)90121-3. PMID 3419199.
- ^ Takayama H, Ishikawa H, Kurihara M, Kitajima M, Aimi N, Ponglux D, Koyama F, Matsumoto K, Moriyama T, Yamamoto LT, Watanabe K, Murayama T, Horie S (2002). "Studies on the synthesis and opioid agonistic activities of mitragynine-related indole alkaloids: discovery of opioid agonists structurally different from other opioid ligands". J. Med. Chem. 45 (9): 1949–56. doi:10.1021/jm010576e. PMID 11960505.
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