SSMEM1
This sandbox is in the article namespace. Either move this page into your userspace, or remove the {{User sandbox}} template. Serine-rich single pass membrane protein 1 is a protein that in humans is encoded by the SSMEM1 gene.[1]
Gene
SSMEM1 is located on the long arm of chromosome 7 (7q32.2) on the sense strand in humans.[2] The human mRNA transcript is 1171 bp long with three exons.[3]
Aliases
In humans, SSMEM1 is also referred to as C7orf45.[4] Human SSMEM1 has a clone name of FLJ40316.[5]
Alternative Splice Variants
SSMEM1 in humans has three alternative splice variants.[6]
Expression
In humans, SSMEM1 is highly expressed in the testes.[7][8][9] In mice, SSMEM1 is expressed in the brain.[10]
Protein
In humans, serine-rich single pass membrane protein 1 is 244 amino acids long with a transmembrane domain region spanning amino acids 35-55.[11] This protein has a domain of unknown function (DUF4636) that spans almost all of the protein (amino acids 1-243).[12] DUF4636 belongs to pfam15468 which is a part of the superfamily cl21285 that is found in eukaryotes and typically 196 to 244 amino acids long.[13] The human protein has a molecular weight of 28036 Da and an isoelectric point of 7.64.[14][15]
Isoforms
Serine-rich single pass membrane protein 1 in humans, has two isoforms.[16]
Protein Composition
Serine-rich single pass membrane protein 1 is predicted to be serine-rich and glycine and leucine-poor in humans.[17] It's primate orthologs are predicted to be serine-rich and leucine-poor as well.[18]In addition, most of the mammal orthologs are serine-rich as well along with one reptile, the American alligator predicted to be serine-rich as well.[19]
Sub-cellular Localization
Serine-rich single pass membrane protein 1 has been predicted to be predominantly nuclear in humans and its orthologs.[20] There are predicted nuclear localization signals seen in the human and most of the ortholog proteins.[21] In addition, there is a predicted peroxisomal targeting signal, SKF-like motif in the human protein and most of the orthologs as well.[22]
Homology
SSMEM1 (Homo Sapiens) is conserved in mammals and less strictly in some reptiles.[23]
The following is a table of human SSMEM1's strict orthologs:[24]
| Genus & Species | Common Name | Accession # | Seq Length | Seq Identity | Seq Similarity |
|---|---|---|---|---|---|
| Homo sapiens | Human | NP_660311.1 | 244 | 100.00% | 100% |
| Gorilla gorilla gorilla | Western lowland gorilla | XP_004046260.1 | 244 | 95.90% | 96% |
| Pongo abelii | Sumatran orangutan | XP_002818493.1 | 243 | 95.50% | 96% |
| Nomascus leucogenys | Northern white-cheeked gibbon | XP_004090272.1 | 244 | 93.40% | 94% |
| Papio anubis | Olive baboon | XP_003896643.1 | 244 | 93.00% | 95% |
| Chlorocebus sabaeus | Green monkey | XP_007981101.1 | 244 | 92.00% | 94% |
| Rhinopithecus roxellana | Golden snub-nosed monkey | XP_010377084.1 | 244 | 91.40% | 95% |
| Canis lupus familiaris | Dog | XP_850606.1 | 244 | 77.50% | 84% |
| Vicugna pacos | Alpaca | XP_006202349.1 | 244 | 75.80% | 85% |
| Leptonychotes weddellii | Weddell seal | XP_006729286.1 | 243 | 77.00% | 85% |
| Ursus maritimus | Polar bear | XP_008704097.1 | 243 | 76.20% | 85% |
| Sus scrofa | Wild boar | XP_005658168.1 | 244 | 75.40% | 82% |
| Felis catus | Cat | XP_003983118.1 | 244 | 73.00% | 80% |
| Bison bison bison | American bison | XP_010829976.1 | 241 | 72.10% | 80% |
| Cavia porcellus | Guinea pig | XP_003475110.1 | 244 | 63.10% | 75% |
| Microtus ochrogaster | Prairie vole | XP_005365835.1 | 247 | 60.70% | 72% |
| Tarsius syrichta | Philippine tarsier | XP_008047786.1 | 239 | 65.70% | 76% |
| Sarcophilus harrisii | Tasmanian devil | XP_003772611.1 | 245 | 58.80% | 72% |
| Echinops telfairi | Lesser hedgehog tenrec | XP_004707938.1 | 242 | 60.80% | 70% |
| Fukomys damarensis | Damaraland mole-rat | XP_010631810.1 | 242 | 63.50% | 75% |
The following is a table of human SSMEM1's less strict orthologs:[25]
| Genus & Species | Common Name | Accession # | Seq Length | Seq Identity | Seq Similarity |
|---|---|---|---|---|---|
| Alligator mississippiensis | American alligator | XP_006265196.1 | 240 | 35.40% | 53% |
| Pelodiscus sinensis | Chinese softshell turtle | XP_006120420.1 | 166 | 27.20% | 60% |
| Alligator sinensis | Chinese alligator | XP_006031905.1 | 148 | 27.80% | 55% |
| Chelonia mydas | Green turtle | XP_007072451.1 | 176 | 28.50% | 55% |
| Chrysemys picta bellii | Painted turtle | XP_008175066.1 | 138 | 23.20% | 62% |
References
- ^ http://www.ncbi.nlm.nih.gov/protein/NP_660311.1
- ^ http://www.ncbi.nlm.nih.gov/gene?LinkName=protein_gene&from_uid=21687171
- ^ http://www.ncbi.nlm.nih.gov/nuccore/197304739
- ^ http://www.ncbi.nlm.nih.gov/gene?LinkName=protein_gene&from_uid=21687171
- ^ http://www.ncbi.nlm.nih.gov/gene?cmd=retrieve&list_uids=136263
- ^ http://www.ncbi.nlm.nih.gov/nuccore/767946816,767946815,767946813,197304739
- ^ http://patft.uspto.gov/netacgi/nph-Parser?Sect2=PTO1&Sect2=HITOFF&p=1&u=/netahtml/PTO/search-bool.html&r=1&f=G&l=50&d=PALL&RefSrch=yes&Query=PN/8586006
- ^ http://www.ncbi.nlm.nih.gov/UniGene/ESTProfileViewer.cgi?uglist=Hs.351816
- ^ http://www.ncbi.nlm.nih.gov/geo/tools/profileGraph.cgi?ID=GDS3834:4246
- ^ http://mouse.brain-map.org/gene/show/51488
- ^ http://www.ncbi.nlm.nih.gov/protein/NP_660311.1
- ^ http://www.ncbi.nlm.nih.gov/protein/NP_660311.1
- ^ http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=259599
- ^ http://www.ncbi.nlm.nih.gov/protein/NP_660311.1
- ^ http://www.phosphosite.org/proteinAction.do?id=13271515&showAllSites=true
- ^ http://www.ncbi.nlm.nih.gov/protein/767946817,767946814,530385477,21687171
- ^ Protein Tools SAPS (Biology Workbench) http://workbench.sdsc.edu/ Volker Brendel, Department of Mathematics, Stanford University, Stanford CA 94305, U.S.A., modified; any errors are due to the modification.
- ^ Protein Tools SAPS (Biology Workbench) http://workbench.sdsc.edu/ Volker Brendel, Department of Mathematics, Stanford University, Stanford CA 94305, U.S.A., modified; any errors are due to the modification.
- ^ Protein Tools SAPS (Biology Workbench) http://workbench.sdsc.edu/ Volker Brendel, Department of Mathematics, Stanford University, Stanford CA 94305, U.S.A., modified; any errors are due to the modification.
- ^ PSORTII http://www.genscript.com/psort/psort2.html
- ^ PSORTII http://www.genscript.com/psort/psort2.html
- ^ PSORTII http://www.genscript.com/psort/psort2.html
- ^ http://blast.ncbi.nlm.nih.gov/Blast.cgi
- ^ http://blast.ncbi.nlm.nih.gov/Blast.cgi
- ^ http://blast.ncbi.nlm.nih.gov/Blast.cgi
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