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Czech Brain Ageing Study

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Czech Brain Ageing Study (CBAS)

The project to establish pilot data for the Czech Brain Ageing Study (CBAS) was initiated in 2005 as a longitudinal follow-up of subjects at risk of Alzheimer disease dementia (AD). A major step forward occurred in 2011 when increased funding led to a more coordinated transfer of know-how between two sites—the Cognitive Center at Department of Neurology, 2nd Medical Faculty, Charles University and Motol University Hospital based in Prague and the International Clinical Research Center (ICRC) based in Brno. CBAS now recruits a large numbers of participants across the two sites and is the only longitudinal study of its kind in the Czech Republic. It is also about to become the largest study to study risk factors for AD in Central and Eastern Europe.[1]

Study design

Participants undergo multimodality brain MRI, comprehensive standardized neuropsychology, genetic and other laboratory examinations (blood, plasma, cerebrospinal fluid assays). The majority of participants also undergo a unique translational, experimental neuropsychology protocol that has been inspired by relevant animal research. This protocol consists of various tests aiming to detect early cognitive and clinical impairment in AD spectrum.[2][3][4] The strong translational aspect of this approach, which includes the use of the human analogue of the Morris Water Maze[5], is aimed at the identification of individuals at preclinical and prodromal stage of AD.[6][7]

International collaboration

The CBAS team is well established and internationally recognized, and has multiple international collaborations including Massachusetts General Hospital, Harvard University (Boston), the Mayo Clinic (Rochester, MN) and University of South Florida (Tampa, USA), as well as University of Queensland (Brisbane, Australia), Drum Tower Hospital and Nanjing University (Nanjing, China), University of Bonn, University of East Anglia (UK) and Karolinska Institutet (Stockholm, Sweden).

Institutions participating in CBAS

  • Cognitive center, Department of Neurology, 2nd Medical Faculty, Charles University and Motol University hospital in Prague

The team at Charles University in Prague specializes in clinical research in the field of cognitive and behavioral neurology, including neuroepidemiology of neurodegenerative disorders leading to various dementia syndromes. The Cognitive center has been a member of the European Alzheimer Disease Consortium (EADC) since 2017, and memorandums were signed to join the European Medical Information Framework (EMIF) and the Global Alzheimer’s Association Interactive Network (GAAIN) networks.

  • International Clinical Research Center at the St. Anne’s University Hospital in Brno (FNUSA-ICRC)

References

  1. ^ Andel R (1 December 2014). "Aging in the Czech republic". The Gerontologist. 54 (6): 893–900. doi:10.1093/geront/gnu047. PMID 24855314.
  2. ^ Chmatalova Z, Vyhnalek M, Laczo J, Hort J, Pospisilova R, Pechova M, Skoumalova A (2017). "Relation of plasma selenium and lipid peroxidation end products in patients with Alzheimer's disease". Physiol Res. 66 (6): 1049–1056. PMID 28937243.
  3. ^ Vyhnálek M, Rubínová E, Marková H, Nikolai T, Laczó J, Andel R, Hort J (2017). "Clock drawing test in screening for Alzheimer's dementia and mild cognitive impairment in clinical practice". Int J Geriatr Psychiatry. 32 (9): 933–939. doi:10.1002/gps.4549. PMID 27466038.
  4. ^ Cerman J, Andel R, Laczo J, Vyhnalek M, Nedelska Z, Mokrisova I, Sheardova K, Hort J (2018). "Subjective Spatial Navigation Complaints - A Frequent Symptom Reported by Patients with Subjective Cognitive Decline, Mild Cognitive Impairment and Alzheimer's Disease". Current Alzheimer Research. 15 (3): 219–228. doi:10.2174/1567205014666171120145349. PMID 29165083.
  5. ^ Laczó J, Markova H, Lobellova V, Gazova I, Parizkova M, Cerman J, Nekovarova T, Vales K, Klovrzova S, Harrison J, Windisch M, Vlcek K, Svoboda J, Hort J, Stuchlik A (2017). "Scopolamine disrupts place navigation in rats and humans: a translational validation of the Hidden Goal Task in the Morris water maze and a real maze for humans". Psychopharmacology (Berl). 234 (4): 535–547. doi:10.1007/s00213-016-4488-2. PMID 27885411.
  6. ^ Pařízková M, Andel R, Lerch O, Marková H, Gažová I, Vyhnálek M, Hort J, Laczó J (2017). "Homocysteine and Real-Space Navigation Performance among Non-Demented Older Adults". Journal of Alzheimers Disease. 55 (3): 951–964. doi:10.3233/JAD-160667. PMID 27802238.
  7. ^ Laczó J, Andel R, Nedelska Z, Vyhnalek M, Vlcek K, Crutch S, Harrison J, Hort J (2017). "Exploring the contribution of spatial navigation to cognitive functioning in older adults". Neurobiol Aging. 51: 67–70. doi:10.1016/j.neurobiolaging.2016.12.003. PMID 28039765.
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