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β-Carboline

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β-Carboline
Chemical structure of β-carboline
Names
Preferred IUPAC name
9H-Pyrido[3,4-b]indole
Other names
  • Norharmane
  • Norharman
  • Carbazoline
  • 2-Azacarbazole
  • 2,9-Diazafluorene
Identifiers
3D model (JSmol)
128414
ChEBI
ChEMBL
ChemSpider
ECHA InfoCard 100.005.418 Edit this at Wikidata
EC Number
  • 205-959-0
KEGG
MeSH norharman
UNII
  • InChI=1S/C11H8N2/c1-2-4-10-8(3-1)9-5-6-12-7-11(9)13-10/h1-7,13H checkY
    Key: AIFRHYZBTHREPW-UHFFFAOYSA-N checkY
  • InChI=1/C11H8N2/c1-2-4-10-8(3-1)9-5-6-12-7-11(9)13-10/h1-7,13H
    Key: AIFRHYZBTHREPW-UHFFFAOYAG
  • c1ccc3c(c1)[nH]c2cnccc23
Properties
C11H8N2
Molar mass 168.20 g/mol
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
checkY verify (what is checkY☒N ?)

β-Carboline, also known as norharman or as 9H-pyrido[3,4-b]indole, is a tricyclic chemical compound and alkaloid.[1] It is the parent structure of the substituted β-carbolines, a large group of alkaloids and synthetic compounds.[1] β-Carboline may be thought of as a cyclized tryptamine.[1] The compound has been found to possess a variety of pharmacological activities, including DNA mutagenic effects, imidazoline receptor interactions, serotonin reuptake inhibition, monoamine oxidase inhibition, cytochrome P450 enzyme inhibition, and inhibition of other enzymes, among others.[1]

See also

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References

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  1. ^ a b c d Cao R, Peng W, Wang Z, Xu A (2007). "beta-Carboline alkaloids: biochemical and pharmacological functions". Curr Med Chem. 14 (4): 479–500. doi:10.2174/092986707779940998. PMID 17305548.
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