Cychlorphine

Cychlorphine
Identifiers
CAS Number	16145-71-4;
PubChem CID	201662;
ChemSpider	174605;
Chemical and physical data
Formula	C23H25ClN4O
Molar mass	408.93 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CC(C1=CC=C(C=C1)Cl)N2CCC(CC2)N3C4=CC=CC=C4N(C3=O)CCC#N;
	InChI InChI=1S/C23H25ClN4O/c1-17(18-7-9-19(24)10-8-18)26-15-11-20(12-16-26)28-22-6-3-2-5-21(22)27(23(28)29)14-4-13-25/h2-3,5-10,17,20H,4,11-12,14-16H2,1H3; Key:SWWAVNFEFVMDAG-UHFFFAOYSA-N;

Cychlorphine is a chemical compound which has been sold as a designer drug, reported in five European countries since 2024, and in the USA. It is similar in chemical structure to known opioid agonists such as brorphine and spirochlorphine, and is claimed to be an opioid with similar or slightly higher potency than fentanyl, but no pharmacological data for cychlorphine has been published.^[1]^[2] It should be noted that investigation into opioids containing an N-cyanoethyl moiety suggest analgesic activity is mediated via the norciception (NOP) receptor and do not substitute for morphine in animal models.^[3]^[4]

Bezitramide

References

^ Chlorphine new drug monograph
^ "European Drug Report 2025 – Full Book" (PDF). European Union Drugs Agency (euda.europa.eu). 6 June 2025.
^ doi: 10.1021/jm00189a024 - Paradoxical Effects of N-Cyanoalkyl Substituents upon the Activities of Several Classes of Opioids
^ https://doi.org/10.1016/j.neuropharm.2019.03.006 - Bifunctional opioid receptor ligands as novel analgesics

[1] Chlorphine new drug monograph

[2] "European Drug Report 2025 – Full Book" (PDF). European Union Drugs Agency (euda.europa.eu). 6 June 2025.

[3] : 10.1021/jm00189a024 - Paradoxical Effects of N-Cyanoalkyl Substituents upon the Activities of Several Classes of Opioids

[4] ttps://doi.org/10.1016/j.neuropharm.2019.03.006 - Bifunctional opioid receptor ligands as novel analgesics

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