Draft:Johannes F. Coy

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  • Comment: I can't find anything in the draft that would conclusively make this notable under WP:NACADEMIC. If that is what's being asserted, please clearly state which of the criteria 1–8 is met, and what evidence supports such an assertion. As for WP:GNG notability, this is not established, as almost all the sources cited are works co-/authored by Coy himself.
    The citations are also wholly inadequate, with many passages unsupported, including the entire 'Awards' section. Private personal details such as DOB and educational background are also not referenced. Please note that per WP:BLP, in articles on living people all material statements, anything potentially contentious, and all private details must be clearly supported by immediate inline citations to reliable published sources. DoubleGrazing (talk) 08:26, 8 April 2023 (UTC)

Johannes F. Coy (*December 15, 1963 in Otzberg) is a German biologist and cancer researcher. He discovered the genes TKTL1[1] and DNaseX[2] (Apo10)[3]. According to the latest findings in evolutionary research, TKTL1 is a key gene that triggered increased neuron formation in the neocortex and structural improvements in the brain compared to Neanderthals, thus enabling the cognitive achievements of modern humans (homo sapiens).[4]

Life and Scientific Work[edit]

Johannes Coy began his biology studies at the Eberhard Karls University in Tübingen in 1985, graduating in 1990 with a focus on molecular and human genetics and biochemistry. In the same year, he transferred to the German Cancer Center (DKFZ) in Heidelberg, where, after completing his diploma thesis (mapping of a tumor suppressor gene in neuroblastoma), he became a member of the research project Molecular Genome Analysis under the direction of Prof. Harald zur Hausen, then head of the DKFZ and later Nobel Prize winner for Medicine.

During this time, he focused on the identification of genes and discovered the two genes TKTL1 and DNaseX (Apo10) in this context. He was awarded summa cum laude in 1996 for his dissertation based on the discovery of the two genes. From his analyses of TKTL1 and DNaseX (Apo10), Coy concluded that both genes hold the potential for new cancer markers for for diagnostic purposes.

In his further scientific work, Coy was from then on involved in the holistic study of tumor cell metabolism, in particular the application of the two genes for the early detection of cancer on the basis of diagnostic tests. He found that the simultaneous presence of TKTL1 and DNaseX (Apo10) in macrophages is indicative of a cancerous disease[3] and participated in the development of a blood test that detects TKTL1 and DNaseX (Apo10) in macrophages.[3]

He also discovered the TKTL1 metabolic pathway and the associated sugar metabolism that enables the prevention and repair of cellular damage.[5][6][7]

As a result of his research, Coy's diagnostic developments include:

  • Epitope detection in monocytes (EDIM) - Biomarker detection method in cells of the innate immune system in blood samples
  • Automated flow cytrometry method
  • Flow cytometry-based blood tests

Johannes Coy holds several patents in the field of cancer research and diagnostics, including DNaseX and TKTL1:

  • DNA encoding DNase and related vectors, host cells and antibodies (DNaseX)[8]
  • Transketolase-related protein (TKTL1)[9]

Awards[edit]

2007: Waltraut Fryda Prize: Awarded at the International Congress of Biological Cancer Medicine for clarifying the role of the TKTL1 gene in the fermentation metabolism of cancer cells.

2006: Diaita Science Prize: Awarded by the Gesellschaft für Ernährungsmedizin und Diätetik e.V. (now Fachgesellschaft für Ernährungstherapie und Prävention (FET) e.V.) at the Medica trade fair for outstanding scientific commitment in the field of cancer research, diagnostics and therapy.

Publications (selection)[edit]

2022

  • Blood-Test Based Targeted Visualization Enables Early Detection of Premalignant and Malignant Tumors in Asymptomatic Individuals[10]

2017

  • EDIM-TKTL1/Apo10 Blood Test: An Innate Immune System Based Liquid Biopsy for the Early Detection, Characterization and Targeted Treatment of Cancer.[11]

2016

  • A key role for transketolase-like 1 in tumor metabolic reprogramming[5]

2013

  • A biomarker based detection and characterization of carcinomas exploiting two fundamental biophysical mechanisms in mammalian cells.[12]

2009

  • Transketolase-like protein 1 (TKTL1) is required for rapid cell growth and full viability of human tumor cells.[13]

2006

  • Expression of transketolase TKTL1 predicts colon and urothelial cancer patient survival. Warburg effect reinterpreted.[6]

2005

  • Mutations in the transketolase-like gene TKTL1. Clinical implications for neurodegenerative diseases, diabetes and cancer.[7]

2000

  • Functional characterization of DNase X, a novel endonuclease expressed in muscle cells.[14]

1996

  • Molecular cloning of tissue-specific transcripts of a transketolase-related gene. Implications for the evolution of new vertebrate genes.[1]
  • Isolation, differential splicing and protein expression of a DNase on the human X chromosome.[2]

References[edit]

  1. ^ a b Johannes F. Coy, Stefan Dübel, Petra Kioschis, Karen Thomas, Gos Micklem, Hajo Delius, Annemarie Poustka (1996-03-15), "Molecular Cloning of Tissue-Specific Transcripts of a Transketolase-Related Gene: Implications for the Evolution of New Vertebrate Genes", Genomics, vol. 32, no. 3, pp. 309–316, doi:10.1006/geno.1996.0124, ISSN 0888-7543, PMID 8838793, retrieved 2022-12-01{{citation}}: CS1 maint: multiple names: authors list (link)
  2. ^ a b J. F. Coy, I. Velhagen, R. Himmele, H. Delius, A. Poustka, H. Zentgraf (April 1996), "Isolation, differential splicing and protein expression of a DNase on the human X chromosome", Cell Death and Differentiation, vol. 3, no. 2, pp. 199–206, ISSN 1350-9047, PMID 17180083, retrieved 2022-12-01{{citation}}: CS1 maint: multiple names: authors list (link)
  3. ^ a b c Coy, Johannes F. (2017-04-20). "EDIM-TKTL1/Apo10 Blood Test: An Innate Immune System Based Liquid Biopsy for the Early Detection, Characterization and Targeted Treatment of Cancer". International Journal of Molecular Sciences. 18 (4): 878. doi:10.3390/ijms18040878. ISSN 1422-0067. PMC 5412459. PMID 28425973.
  4. ^ Pinson, Anneline; Xing, Lei; Namba, Takashi; Kalebic, Nereo; Peters, Jula; Oegema, Christina Eugster; Traikov, Sofia; Reppe, Katrin; Riesenberg, Stephan; Maricic, Tomislav; Derihaci, Razvan; Wimberger, Pauline; Pääbo, Svante; Huttner, Wieland B. (2022-09-09). "Human TKTL1 implies greater neurogenesis in frontal neocortex of modern humans than Neanderthals". Science. 377 (6611): eabl6422. doi:10.1126/science.abl6422. ISSN 0036-8075. PMID 36074851. S2CID 252161562.
  5. ^ a b Santiago Diaz-Moralli, Esther Aguilar, Silvia Marin, Johannes F. Coy, Mieke Dewerchin, Maciek R. Antoniewicz, Oscar Meca-Cortés, Leen Notebaert, Bart Ghesquière, Guy Eelen, Timothy M. Thomson, Peter Carmeliet, Marta Cascante (2016-08-09), "A key role for transketolase-like 1 in tumor metabolic reprogramming", Oncotarget, vol. 7, no. 32, pp. 51875–51897, doi:10.18632/oncotarget.10429, ISSN 1949-2553, PMC 5239521, PMID 27391434{{citation}}: CS1 maint: multiple names: authors list (link)
  6. ^ a b S Langbein, M Zerilli, A zur Hausen, W Staiger, K Rensch-Boschert, N Lukan, J Popa, M P Ternullo, A Steidler, C Weiss, R Grobholz, F Willeke, P Alken, G Stassi, P Schubert, J F Coy (Feb 2006), "Expression of transketolase TKTL1 predicts colon and urothelial cancer patient survival: Warburg effect reinterpreted", British Journal of Cancer, vol. 94, no. 4, pp. 578–585, doi:10.1038/sj.bjc.6602962, ISSN 0007-0920, PMC 2361175, PMID 16465194{{citation}}: CS1 maint: multiple names: authors list (link)
  7. ^ a b Johannes F. Coy, Dirk Dressler, Juergen Wilde, Peter Schubert (2005), "Mutations in the transketolase-like gene TKTL1: clinical implications for neurodegenerative diseases, diabetes and cancer", Clinical Laboratory, vol. 51, no. 5–6, pp. 257–273, ISSN 1433-6510, PMID 15991799, retrieved 2022-12-01{{citation}}: CS1 maint: multiple names: authors list (link)
  8. ^ EP0842278B1, Zentgraf, Hanswalter; Poustka, Annemarie & Coy, Johannes et al., "Protein mit dnase-aktivität", issued 2005-11-09 
  9. ^ EP0840789B1, Poustka, Annemarie & Coy, Johannes, "Transketolase-verwandtes protein", issued 2006-05-31 
  10. ^ Simon Burg, Audrey Laure Céline Grust, Oliver Feyen, Katja Failing, Gamal-André Banat, Johannes F Coy, Martin Grimm, Martin Gosau, Ralf Smeets (2022-05-20). "Blood-Test Based Targeted Visualization Enables Early Detection of Premalignant and Malignant Tumors in Asymptomatic Individuals" (PDF). Clinandmedimages. Retrieved 2022-12-08.{{cite web}}: CS1 maint: multiple names: authors list (link)
  11. ^ Johannes Coy (2017-04-20), "EDIM-TKTL1/Apo10 Blood Test: An Innate Immune System Based Liquid Biopsy for the Early Detection, Characterization and Targeted Treatment of Cancer", International Journal of Molecular Sciences, vol. 18, no. 4, p. 878, doi:10.3390/ijms18040878, ISSN 1422-0067, PMC 5412459, PMID 28425973
  12. ^ Martin Grimm, Steffen Schmitt, Peter Teriete, Thorsten Biegner, Arnulf Stenzl, Jörg Hennenlotter, Hans-Joachim Muhs, Adelheid Munz, Tatjana Nadtotschi, Klemens König, Jörg Sänger, Oliver Feyen, Heiko Hofmann, Siegmar Reinert, Johannes F Coy (Dec 2013), "A biomarker based detection and characterization of carcinomas exploiting two fundamental biophysical mechanisms in mammalian cells", BMC Cancer, vol. 13, no. 1, p. 569, doi:10.1186/1471-2407-13-569, ISSN 1471-2407, PMC 4235042, PMID 24304513{{citation}}: CS1 maint: multiple names: authors list (link)
  13. ^ Xiaojun Xu, Axel zur Hausen, Johannes F. Coy, Martin Löchelt (2009-03-15), "Transketolase-like protein 1 (TKTL1) is required for rapid cell growth and full viability of human tumor cells", International Journal of Cancer, vol. 124, no. 6, pp. 1330–1337, doi:10.1002/ijc.24078, PMID 19065656, S2CID 20985253, retrieved 2022-12-01{{citation}}: CS1 maint: multiple names: authors list (link)
  14. ^ Marek Los, Dagmar Neubüser, Johannes F. Coy, Malgorzata Mozoluk, Annemarie Poustka, Klaus Schulze-Osthoff (2000-06-01), "Functional Characterization of DNase X, a Novel Endonuclease Expressed in Muscle Cells", Biochemistry, vol. 39, no. 25, pp. 7365–7373, doi:10.1021/bi000158w, ISSN 0006-2960, PMID 10858283, retrieved 2022-12-01{{citation}}: CS1 maint: multiple names: authors list (link)