Kelch protein - Wikipedia

Kelch Protein Family

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Accepted and created as Kelch protein. Based on Google, it's clearly notable. Shalom ^Hello 16:11, 17 August 2007 (UTC) Kelch proteins (and Kelch-like proteins) are proteins that have repeated kelch domains. Most Kelch proteins also have a BTB (defn) domain. Each kelch domain forms the blade of a propellar structure, with the repeated kelch domains forming a Beta-propellar. The structure of this Beta-propellar is known but the function is not characterised.

Structure

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Function

The function of Kelch proteins is unknow. However they commonly seen to associate with actin tails

Oraganisms

The first Kelch protein (from which this family derrives its name) was isolated from Drosophila. It has also been isolated in many other animals [INSERT], bacteria, fungi, and even virus (restricted to Poxviridae)

Sources

Structure of the Keap1:Nrf2 interface provides mechanistic insight into Nrf2 signaling Shih-Ching Lo, Xuchu Li, Michael T Henzl, Lesa J Beamer, and Mark Hannink EMBO J. 2006 August 9; 25(15): 3605–3617. Published online 2006 August 3. doi: 10.1038/sj.emboj.7601243. PMCID: 1538563

The BTB domain, found primarily in zinc finger proteins, defines an evolutionarily conserved family that includes several developmentally regulated genes in Drosophila. S Zollman, D Godt, G G Privé, J L Couderc, and F A Laski Proc Natl Acad Sci U S A. 1994 October 25; 91(22): 10717–10721. PMCID: 45093