Edward Callaway
Edward M. Callaway | |
|---|---|
| Born | March 15, 1962 Los Angeles, California, USA |
| Nationality | American |
| Alma mater | Stanford University (B.S.), California Institute of Technology (Ph.D.) |
| Known for | Neural circuit mapping, visual cortex research, development of viral tools for neuroscience |
| Awards | National Academy of Sciences (2019), American Academy of Arts and Sciences (2012), AAAS Fellow (2010) |
| Scientific career | |
| Fields | Neuroscience |
| Institutions | Salk Institute for Biological Studies |
Edward M. Callaway (born March 15, 1962) is an American neuroscientist recognized for his research on the organization and function of neocortical circuits, particularly within the visual system. He is known for developing innovative viral tools to map neural connections, a method known as viral neuronal tracing. He developed the monosynaptic-rabies tracing system and has shown how specific cortical and thalamic cell types integrate visual information.[1] Callaway was elected to the National Academy of Sciences in 2019.[2]
Early life and education
[edit]Edward Matthew Callaway was born on March 15, 1962, in Los Angeles, California. He earned his Bachelor of Science in Biology from Stanford University in 1984. He then pursued a Ph.D. in Neurobiology at the California Institute of Technology, completing his doctorate in 1988 under the mentorship of David Van Essen. His doctoral research focused on neuromuscular development.[3]
Following his Ph.D., Callaway conducted postdoctoral research with Larry Katz at the Rockefeller University, and later at Duke University, investigating the development of visual cortical circuitry.[4]
Academic career
[edit]In 1995, Callaway joined the Salk Institute for Biological Studies as an Assistant Professor in the Systems Neurobiology Laboratory. He currently holds the position of Professor and is the Vincent J Coates Chair in Molecular Neurobiology at the institute.[5]
Research contributions
[edit]Callaway's research has significantly advanced the understanding of neural circuits in the cerebral cortex, with a particular emphasis on the visual system. His notable contributions include:
- Development of Viral Tools for Circuit Mapping: Callaway developed the method for using a modified rabies viruses to trace monosynaptic connections between neurons. This technique allows for the mapping of direct synaptic inputs to specific neurons, providing unprecedented insights into neural circuit organization.[5]
- Visual Cortex Organization: His studies have elucidated the functional organization of the primate visual cortex, detailing how different cell types contribute to visual processing and how information is integrated across cortical layers.[6]
- Cortico-Thalamo-Cortical Circuits: His recent work involves mapping cortico-thalamo-cortical pathways, revealing complementary organizations of driver and modulator circuits in the mouse visual system.[7]
- Cell-Type Specific Cortical Pathways: A 2024 study led by Callaway used single-cell profiling and circuit tracing to identify distinct excitatory neuron types that project to different cortical layers and brain regions, deepening our understanding of cell-type-specific connectivity in the visual cortex.[8]
Awards and honors
[edit]- Alfred P. Sloan Fellow (1992–1994)[9]
- McKnight Technological Innovations in Neurosciences Award (2006)[10]
- Fellow of the American Association for the Advancement of Science (2010)[5]
- Fellow of the American Academy of Arts and Sciences (2012)[4]
- Krieg Cortical Discoverer Award (2013)[11]
- Election to the National Academy of Sciences (2019)[2]
References
[edit]- ^ Wickersham, Ian R.; Lyon, David C.; Barnard, Rhonda J.O.; Mori, Toshio; Finke, Susanne; Conzelmann, Karl-Klaus; Young, James A.T.; Callaway, Edward M. (March 2007). "Monosynaptic restriction of transsynaptic tracing from single, genetically targeted neurons". Neuron. 53 (5): 639–647. doi:10.1016/j.neuron.2007.01.033. PMC 2629495. PMID 17329205.
- ^ a b "Member Directory - Edward M. Callaway". National Academy of Sciences. Retrieved March 28, 2025.
- ^ "Edward Callaway". The Kavli Foundation. Retrieved March 28, 2025.
- ^ a b "Edward Matthew Callaway". American Academy of Arts and Sciences. Retrieved March 28, 2025.
- ^ a b c "Edward Callaway, PhD". Salk Institute for Biological Studies. Retrieved March 28, 2025.
- ^ Callaway, Edward M. (1998). "Local circuits in primary visual cortex of the macaque monkey". Annual Review of Neuroscience. 21 (1): 47–74. doi:10.1146/annurev.neuro.21.1.47. PMID 9530491.
- ^ Cassidy, Rachel M.; Macias, Angel V.; Lagos, Willian N.; Ugorji, Chukwuma; Callaway, Edward M. (2025). "Complementary Organization of Mouse Driver and Modulator Cortico-Thalamo-Cortical Circuits". Journal of Neuroscience. 45 (5): e1167242024. doi:10.1523/JNEUROSCI.1167-24.2024. PMC 11780356. PMID 39824633.
- ^ Luo, Tingjia; Chun, James; Macias, Angel V.; Callaway, Edward M. (2024). "Transcriptomic and projection-specific characterization of mouse layer 5 cortical neurons". Cell. 187 (15): 3467–3483.e17. doi:10.1038/s41586-023-06823-w. PMID 38092919.
- ^ "Sloan Research Fellows Database". Sloan Foundation. Retrieved March 28, 2025.
- ^ "Technological Innovations in Neuroscience Awards - Past Awardees". The McKnight Foundation. Retrieved March 28, 2025.
- ^ "Past Award Winners - Krieg Cortical Discoverer Award". Society for Neuroscience. Retrieved March 28, 2025.
- 1962 births
- Living people
- Stanford University alumni
- California Institute of Technology alumni
- American neuroscientists
- Scientists from Los Angeles
- Salk Institute for Biological Studies people
- Members of the United States National Academy of Sciences
- Fellows of the American Academy of Arts and Sciences
- Fellows of the American Association for the Advancement of Science
- Sloan Fellows