Adapalene/benzoyl peroxide
 | |
| Combination of | |
|---|---|
| Adapalene | Retinoid |
| Benzoyl peroxide | Peroxide |
| Clinical data | |
| Trade names | Epiduo, Epiduo Forte, Tactupump Forte, Desarena, Effezel, Belakne Combi, Aciduo |
| AHFS/Drugs.com | Micromedex Detailed Consumer Information |
| License data | |
| Routes of administration | Topical |
| ATC code | |
| Legal status | |
| Legal status | |
| Identifiers | |
| CAS Number | |
| KEGG | |
  (what is this?) (verify) | |
Adapalene/benzoyl peroxide, sold under the brand name Epiduo among others, is a fixed-dose combination medication for the treatment of acne vulgaris.[2][3] It is a combination of adapalene, a retinoid; and benzoyl peroxide.[2][3]
It is available as a generic medication.[4] In 2022, it was the 292nd most commonly prescribed medication in the United States, with more than 400,000 prescriptions.[5][6]
Medical uses
[edit]Adapalene/benzoyl peroxide is indicated for the topical treatment of acne vulgaris.[2][3]
Side effects
[edit]Commonly reported side effects include the following:[2][3]
Research
[edit]Meta-analysis of clinical trials has shown this combined therapy to be more effective than either of its ingredients by themselves.[7]
The use of adapalene/benzoyl peroxide in combination with oral antibiotics (lymecycline) has been studied;[8] the combination was well tolerated and showed an improved success rate compared to those receiving only antibiotics (47.6% vs. 33.7%, P = 0.002).
References
[edit]- ^ "Adapax (Nova Pharmaceuticals Australasia Pty Ltd)". Therapeutic Goods Administration (TGA). 16 April 2025. Retrieved 3 May 2025.
- ^ a b c d e "Epiduo- adapalene and benzoyl peroxide gel". DailyMed. 21 February 2018. Retrieved 15 May 2022.
- ^ a b c d e "Epiduo Forte- adapalene and benzoyl peroxide gel". DailyMed. 27 April 2022. Retrieved 15 May 2022.
- ^ "Competitive Generic Therapy Approvals". U.S. Food and Drug Administration (FDA). 29 June 2023. Archived from the original on 29 June 2023. Retrieved 29 June 2023.
- ^ "The Top 300 of 2022". ClinCalc. Archived from the original on 30 August 2024. Retrieved 30 August 2024.
- ^ "Adapalene; Benzoyl Peroxide Drug Usage Statistics, United States, 2013 - 2022". ClinCalc. Retrieved 30 August 2024.
- ^ Tan J, Gollnick HP, Loesche C, Ma YM, Gold LS (August 2011). "Synergistic efficacy of adapalene 0.1%-benzoyl peroxide 2.5% in the treatment of 3855 acne vulgaris patients". The Journal of Dermatological Treatment. 22 (4): 197–205. doi:10.3109/09546631003681094. PMID 20666678. S2CID 34631151.
- ^ Dréno B, Kaufmann R, Talarico S, Torres Lozada V, Rodríguez-Castellanos MA, Gómez-Flores M, et al. (August 2011). "Combination therapy with adapalene-benzoyl peroxide and oral lymecycline in the treatment of moderate to severe acne vulgaris: a multicentre, randomized, double-blind controlled study". The British Journal of Dermatology. 165 (2): 383–90. doi:10.1111/j.1365-2133.2011.10374.x. PMID 21495995. S2CID 21793660.
