Hedonic sensitization
Hedonic sensitization is a neuropsychological process in which repeated exposure to a rewarding stimulus leads to a heightened hedonic or motivational response over time, rather than the diminishing response typically expected. This phenomenon contrasts with hedonic adaptation, the tendency for affective responses to stabilize or return to a baseline despite sustained positive input, and hedonic desensitization, in which the ability to experience pleasure is reduced due to neural downregulation or overstimulation of reward systems.[1][2]
The concept was formalized as part of the incentive-sensitization theory of addiction, developed by Robinson and Berridge, which distinguishes between “liking” (hedonic impact) and “wanting” (incentive salience). Their model proposes that repeated exposure to drugs or other reinforcing stimuli sensitizes brain circuits related to “wanting,” but not necessarily to “liking,” explaining why people may crave substances they no longer find pleasurable.[3][1]
Neurobiological mechanisms
[edit]At the core of hedonic sensitization is the mesolimbic dopamine system, including the ventral tegmental area (VTA) and the nucleus accumbens (NAc). These areas are central to reward processing and reinforcement learning. Repeated activation of this system enhances dopaminergic reactivity to cues associated with rewarding stimuli, making them increasingly attractive over time.[4][5]
Neuroimaging studies support this model. For example, in a 2016 fMRI study, long-term cannabis users showed increased activation in reward regions (including the NAc and orbitofrontal cortex) when exposed to cannabis cues, consistent with the idea of sensitized neural response to hedonic stimuli.[6]
Comparison with related concepts
[edit]Hedonic sensitization differs from other affective phenomena such as hedonic adaptation—a process where people return to a baseline level of happiness after positive or negative events. It also contrasts with tolerance, in which increasing quantities of a stimulus are required to achieve the same effect. In hedonic sensitization, motivational salience increases, even when subjective pleasure does not.[5][1]
The concept also links closely to incentive salience, a psychological mechanism describing how certain cues become disproportionately powerful in driving behavior. Incentive sensitization is thought to intensify cue-reactivity without necessarily enhancing the hedonic experience.[3]
Applications
[edit]Addiction
[edit]The most studied domain of hedonic sensitization is substance addiction. Repeated drug use enhances the motivational value of drug-associated cues, which can result in persistent craving and relapse even after extended periods of abstinence. This explains why “wanting” often outlives “liking” in drug addiction.[3][5][1]
A study demonstrated that at-risk drinkers showed greater cue-induced "wanting" for alcohol without a corresponding increase in "liking", supporting the theory's core claim.[7]
Food reward and obesity
[edit]Hedonic sensitization is also seen in responses to palatable foods. Repeated consumption of sweet or high-fat foods can increase their motivational pull, contributing to overeating and obesity. Evidence that sensitization to the rewarding properties of food mirrors patterns seen in drug addiction has been found.[2]
Similarly, researchers identified a phenomenon they termed "hedonic escalation", where food tasted better with each consumption occasion, possibly due to sensitization mechanisms.[8]
Behavioral addictions
[edit]Beyond substance use, sensitization has been implicated in behavioral addictions like video gaming. A 2022 study showed that heavy video game users reported increasing hedonic pleasure with repeated play, suggesting sensitization of reward-related processes.[9]
Critiques and limitations
[edit]While widely cited, the hedonic sensitization model is not without criticisms. Not all individuals demonstrate sensitization, suggesting individual variability due to genetic, contextual, or psychological factors. Furthermore, the theory emphasizes positive reinforcement, and some researchers argue that negative reinforcement (e.g., avoiding withdrawal or distress) is equally important in understanding addiction.[5][1]
See also
[edit]- Hedonic desensitization
- Incentive-sensitization theory
- Addiction neuroscience
- Hedonic treadmill
- Behavioral addiction
- Dopamine hypothesis of addiction
References
[edit]- ^ a b c d e Berridge, Kent C.; Robinson, Terry E. (2008). "The incentive sensitization theory of addiction: Some current issues". Philosophical Transactions of the Royal Society B. 363 (1507): 3137–3146. doi:10.1098/rstb.2008.0093. PMC 2607325. PMID 18640920.
- ^ a b Temple, Jennifer L. (2016). "Behavioral sensitization of the reinforcing value of food: What food and drugs have in common". Preventive Medicine. 92: 77–80. doi:10.1016/j.ypmed.2016.06.020. PMID 27329583.
- ^ a b c Robinson, Terry E.; Berridge, Kent C. (2001). "Incentive-sensitization and addiction" (PDF). Addiction. 96 (1): 103–114. doi:10.1046/j.1360-0443.2001.9611038.x. PMID 11177523.
- ^ Koob, George F.; Le Moal, Michel (1997). "Drug abuse: hedonic homeostatic dysregulation" (PDF). Science. 278 (5335): 52–58. doi:10.1126/science.278.5335.52. PMID 9311936.
- ^ a b c d Berridge, Kent C.; Robinson, Terry E. (2016). "Liking, wanting, and the incentive-sensitization theory of addiction" (PDF). American Psychologist. 71 (8): 670–679. doi:10.1037/amp0000059. PMID 27841462.
- ^ Filbey, Francesca M.; Ketcherside, Angelica; Dunlop, John (2016). "fMRI study of neural sensitization to hedonic stimuli in long-term, daily cannabis users". Human Brain Mapping. 37 (11): 3431–3443. doi:10.1002/hbm.23250. PMID 27378049.
- ^ Ostafin, Brian D.; Marlatt, G. Alan (2010). "Testing the incentive-sensitization theory with at-risk drinkers: Wanting, liking, and alcohol consumption". Psychology of Addictive Behaviors. 24 (3): 381–388. doi:10.1037/a0019043. PMID 20307124.
- ^ Crolic, Cammy; Janiszewski, Chris (2016). "Hedonic escalation: When food just tastes better and better". Journal of Consumer Research. 43 (3): 388–407. doi:10.1093/jcr/ucw030 (inactive 22 June 2025).
{{cite journal}}: CS1 maint: DOI inactive as of June 2025 (link) - ^ Walia, Brijesh; Kim, Jaewook; Ijere, Isidore; Sanders, Steve (2022). "Video game addictive symptom level, use intensity, and hedonic experience: Cross-sectional questionnaire study". JMIR Serious Games. 10 (2): e33661. doi:10.2196/33661. PMID 35311676.