Mitotic DNA Synthesis

Mitotic DNA Synthesis (MiDAS) is a unique form of DNA replication that occurs during the mitotic phase of the cell cycle. This phenomenon was first discovered is U2OS osteosarcoma cancer cell lines in 2015,^[1] and was later discovered in S. cerevisiae in 2020.^[2]

References

^ Minocherhomji, Sheroy; Ying, Songmin; Bjerregaard, Victoria A.; Bursomanno, Sara; Aleliunaite, Aiste; Wu, Wei; Mankouri, Hocine W.; Shen, Huahao; Liu, Ying; Hickson, Ian D. (December 2015). "Replication stress activates DNA repair synthesis in mitosis". Nature. 528 (7581): 286–290. Bibcode:2015Natur.528..286M. doi:10.1038/nature16139. ISSN 1476-4687. PMID 26633632.
^ Ivanova, Tsvetomira; Maier, Michael; Missarova, Alsu; Ziegler-Birling, Céline; Dam, Monica; Gomar-Alba, Mercè; Carey, Lucas B.; Mendoza, Manuel (2020-05-08). "Budding yeast complete DNA synthesis after chromosome segregation begins". Nature Communications. 11 (1): 2267. Bibcode:2020NatCo..11.2267I. doi:10.1038/s41467-020-16100-3. ISSN 2041-1723. PMC 7210879. PMID 32385287.

[1] Minocherhomji, Sheroy; Ying, Songmin; Bjerregaard, Victoria A.; Bursomanno, Sara; Aleliunaite, Aiste; Wu, Wei; Mankouri, Hocine W.; Shen, Huahao; Liu, Ying; Hickson, Ian D. (December 2015). "Replication stress activates DNA repair synthesis in mitosis". Nature. 528 (7581): 286–290. Bibcode:2015Natur.528..286M. doi:10.1038/nature16139. ISSN 1476-4687. PMID 26633632.

[2] Ivanova, Tsvetomira; Maier, Michael; Missarova, Alsu; Ziegler-Birling, Céline; Dam, Monica; Gomar-Alba, Mercè; Carey, Lucas B.; Mendoza, Manuel (2020-05-08). "Budding yeast complete DNA synthesis after chromosome segregation begins". Nature Communications. 11 (1): 2267. Bibcode:2020NatCo..11.2267I. doi:10.1038/s41467-020-16100-3. ISSN 2041-1723. PMC 7210879. PMID 32385287.

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