ADX-71441: Difference between revisions
Themonkey942 (talk | contribs) ←Created page with ''''ADX-71441''' is a GABA<sub>B</sub> receptor positive allosteric modulator currently being investigated as a potential treatement for anxiety, epilepsy, pain and other conditions.{{Chembox | Name = ADX71441 | ImageFile = N-(5-(4-(4-Chloro-3-fluorobenzyl)-6-methoxy-3,5-dioxo-4,5-dihydro-1,2,4-triazin-2(3h)-yl)-2-fluorophenyl)acetamide.png | IUPACName = N-[5-[4-[(4-chloro-3-fluorophenyl)methyl]...' |
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Revision as of 13:37, 3 February 2024
ADX-71441 is a GABAB receptor positive allosteric modulator currently being investigated as a potential treatement for anxiety, epilepsy, pain and other conditions.
-6-methoxy-3,5-dioxo-4,5-dihydro-1,2,4-triazin-2(3h)-yl)-2-fluorophenyl)acetamide.png?lang=en) | |
| Names | |
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| IUPAC name
N-[5-[4-[(4-chloro-3-fluorophenyl)methyl]-6-methoxy-3,5-dioxo-1,2,4-triazin-2-yl]-2-fluorophenyl]acetamide
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| Identifiers | |
3D model (JSmol)
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PubChem CID
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| Properties | |
| C19H15ClF2N4O4 | |
| Molar mass | 436.80 g·mol−1 |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Therapeutic potential
Addiction
ADX-71441 has been shown to reduce alcohol consumption.[1] This result was observed in both alcohol dependent and non-dependent animals.[2]
There also was trials about nicotine addiction, which showed positive results: ADX-71441 was able to decrease some withdrawal symptoms of nicotine withdrawal.[3]
Anxiety
This compound has also been shown to reduce anxiety in people with PTSD.[4]
Pain
Experiments have shown that this compound was able to decrease hypersensitivity to pain in mice, Guinea pigs and rats.[4]
Tolerance
ADX-71441 has been shown to have less tolerance and side effects than direct GABAB agonists, such as baclofen.[2]
- ^ "Addex Reports ADX71441 Reduces Alcohol Intake in a Preclinical Model of Chronic Alcohol Dependence". Addex therapeutics. Retrieved 2024-02-03.
- ^ a b Augier, Eric; Dulman, Russell S.; Damadzic, Ruslan; Pilling, Andrew; Hamilton, J. Paul; Heilig, Markus (2017-08). "The GABAB Positive Allosteric Modulator ADX71441 Attenuates Alcohol Self-Administration and Relapse to Alcohol Seeking in Rats". Neuropsychopharmacology. 42 (9): 1789–1799. doi:10.1038/npp.2017.53. ISSN 1740-634X.
{{cite journal}}: Check date values in:|date=(help) - ^ "Addex ADX71441 Positive Results in Preclinical Model of Nicotine Addiction". Addex therapeutics. Retrieved 2024-02-03.
- ^ a b . https://www.sciencedirect.com/science/article/abs/pii/S0028390816305135.
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