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Post-Treatment imaging
[edit]Following treatment with 90Y, imaging is performed to evaluate 90Y delivery and absorption to evaluate coverage of target regions and involvement of normal tissue. This is typically performed using Bremsstrahlung imaging with single-photon emission computed tomography CT (SPECT/CT), or using 90Y position imaging with positron emission tomography CT (PET/CT).
Bremsstrahlung imaging in 90Y therapy
[edit]As 90Y undergoes beta decay, the particles decelerate and, in turn, emit broad spectrum bremsstrahlung radiation that can be detected with standard gamma cameras or SPECT.[1][2] These modalities provide information about radioactive uptake, however, there is poor spatial information.[1][2] Consequently, it is challenging to delineate anatomy and thereby evaluate tumor and normal tissue uptake. This led to the development of SPECT/CT, which combines the functional information of SPECT with the spatial information of CT, to allow for more accurate 90Y localization.[1][2]
Positron emission tomography
[edit]PET/CT and PET/MRI have superior spatial resolution compared to SPECT/CT because PET directly detects emitted positrons.[1][2] This allows for better assessment of microsphere distribution and dose absorption. However, both PET/CT and PET/MRI are less widely available and more costly.[1][2]
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- ^ a b c d e Rice, Mitchell; Krosin, Matthew; Haste, Paul (2021-10). "Post Yttrium-90 Imaging". Seminars in Interventional Radiology. 38 (4): 460–465. doi:10.1055/s-0041-1735569. ISSN 0739-9529. PMC 8497086. PMID 34629714.
{{cite journal}}: Check date values in:|date=(help) - ^ a b c d e Tong, Aaron K. T.; Kao, Yung Hsiang; Too, Chow Wei; Chin, Kenneth F. W.; Ng, David C. E.; Chow, Pierce K. H. (2016-06). "Yttrium-90 hepatic radioembolization: clinical review and current techniques in interventional radiology and personalized dosimetry". The British Journal of Radiology. 89 (1062): 20150943. doi:10.1259/bjr.20150943. ISSN 1748-880X. PMC 5258157. PMID 26943239.
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