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User:ProfessorPaulFeinstein

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Paul Feinstein
BornSeptember 14, 1964
New York, NY, U.S.
CitizenshipAmerican
Alma materUniversity of Pennsylvania B.A, Columbia. University Ph.D.
Known forFunctionality of Odorant Receptors
AwardsBristol-Myers Squibb postdoctoral fellowship in basic neurosciences (1995), Kirby Foundation postdoctoral fellowship (2000)
Scientific career
FieldsOlfaction, Axon Guidance, Gene Choice, Odorant Receptors, Sense of Smell
InstitutionsHunter College, CUNY

Paul Feinstein is an American professor at the City University of New York with dual appointments at Hunter College, CUNY and The Graduate Center. His research is focused on Odorant Receptors and their role in Odor Detection, Axon Guidance and Singular Gene Choice.

Early life and education

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Born on September 14, 1964, in Booth Memorial Hospital, Paul Feinstein is the son of Claude Rose Feinstein (nee Jacob) and Jack Feinstein. Paul’s mother is a retired M.D.; she obtained her medical degree from the l'ecole de Medecine at University of Paris after WWII. As a foreign graduate obtained a second medical degree at Georgetown. One of the first batch of Doctors in the United States that obtained speciality in addiction disorders. Paul’s father worked as an aerospace engineer at Fairchild Industries for 25 years until his passing. His father helped bring one the of the pioneering ATS-F and SMM satellites. Paul's mother remarried Mark Levine, MBA, CPA, at a FHA program that renovated and constructed regional hospitals including those in NYC.

Career

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Feinstein’s first professional position was as a Research Assistant in the lab of Professor Randall Reed at Johns Hopkins School of Medicine between 1986-1989. Dr Reed's lab identified three core components of the olfactory signal transduction cascade: Gαolf, ACIII, and the CNG2A.

After his Ph.D., Feinstein returned to study olfaction/sense of smell with Dr. Peter Mombaerts at The Rockefeller University in 1995.

He has been studying olfaction in his own lab at Hunter College, CUNY since 2007.

Biotech

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After the publication of his MouSensor paper in Cell Reports that provided a foundation to identify odors for all human receptors, he co-founded MouSensor, LLC. in 2016, rebranded as Yesse Technologies, Inc in 2019. The company closed during the COVID-19 pandemic in 2021.

Selected Publications

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  • Commonality of Odorant Receptor Choice Mechanism Revealed by Analysis of a Highly Represented Odorant Receptor Transgene.

Melanie Makhlouf, Charlotte D’Hulst, Masayo Omura, Alessandro Rosa, Raena Mina, Sergio Bernal-Garcia, Eugene Lempert, Luis R. Saraiva, Paul Feinstein Deposited in bioRxiv: May 5, 2022 Published in journal: Not yet (in revision with Cell Reports). bioRxiv 2022.05.05.489571; doi: https://doi.org/10.1101/2022.05.05.489571

  • Rapid Degradation of the Human ACE2 Receptor Upon Binding and Internalization of SARS-CoV-2-Spike-RBD Protein.

Paul Feinstein (2024) bioRxiv 2024.03.07.583884; doi: https://doi.org/10.1101/2024.03.07.583884 https://www.biorxiv.org/content/10.1101/2024.03.07.583884v1.full.pdf

  • Coronavirus Spike-RBD Variants Differentially Bind to the Human ACE2 Receptor.

Paul Feinstein (2024). bioRxiv 2024.03.07.583944; doi: https://doi.org/10.1101/2024.03.07.583944 https://www.biorxiv.org/content/10.1101/2024.03.07.583944v1.full.pdf

  • Clustering of vomeronasal receptor genes is required for transcriptional stability but not for choice.

Dietschi Q, Tuberosa J, Fodoulian L, Boillat M, Kan C, Codourey J, Pauli V, Feinstein P, Carleton A, Rodriguez I.Sci Adv. 2022 Nov 18;8(46):eabn7450. doi: 10.1126/sciadv.abn7450. Epub 2022 Nov 16.

  • High rates of plasmid cotransformation in E. coli overturn the clonality myth and reveal colony development.

Tomoiaga D, Bubnell J, Herndon L, Feinstein P.

Sci Rep. 2022 Jul 7;12(1):11515. doi: 10.1038/s41598-022-14598-9.PMID: 35798773 Altmetric of 215 https://www.nature.com/articles/s41598-022-14598-9/metrics This article is in the 98th percentile (ranked 4,858th) of the 436,104 tracked articles of a similar age in all journals and the 98th percentile (ranked 61st) of the 4,077 tracked articles of a similar age in Scientific Reports Ranked in the top 35 of 21840 papers published in scientific reports in 2022: https://www.nature.com/collections/jhjibhhicg/

  • A genetic platform for functionally profiling odorant receptors in olfactory cilia ex vivo

Omura M, Takabatake Y, Lempert E, Benjamin-Hong S, D'Hulst C, Feinstein P. Sci Signal. 2022 Aug 9;15(746):eabm6112. doi: 10.1126/scisignal.abm6112. Epub 2022 Aug 9.PMID: 35944068 Altmetric of 65 https://sciencesignaling.altmetric.com/details/133859666/ In the top 5% of all research outputs scored by Altmetric

  • Olfactory expression of trace amine-associated receptors requires cooperative cis-acting enhancers.

Shah A, Ratkowski M, Rosa A, Feinstein P, Bozza T. Nat Commun. 2021 Jun 18;12(1):3797. doi: 10.1038/s41467-021-23824-3.

  • Single-cell sperm transcriptomes and variants from fathers of children with and without autism spectrum disorder.

Tomoiaga D, Aguiar-Pulido V, Shrestha S, Feinstein P, Levy SE, Mason CE, Rosenfeld JA. NPJ Genom Med. 2020 Feb 21;5:14. doi: 10.1038/s41525-020-0117-4. eCollection 2020.

  • MouSensor: A Versatile Genetic Platform to Create Super Sniffer Mice for Studying Human Odor Coding. (2016)

Charlotte D’Hulst, Raena B. Mina, Zachary Gershon, Sophie Jamet, AntonioCerullo, Delia Tomoiaga, Li Bai, Leonardo Belluscio, Matthew Rogers, Yevgeniy Sirotin, and Paul Feinstein. Cell Rep. 2016 Jul 26;16(4):1115-25. doi: 10.1016/j.celrep.2016.06.047. Epub 2016 Jul 7. Altmetric of 307 https://www.altmetric.com/details/9425554

  • Axonal Wiring through Odorant Receptors.

P. Mombaerts and P. Feinstein. S. Grillner and A.M. Graybiel ed. Microcircuits.(2005) The interface between Neurons and Global Brain Function. Dahlem Workshop Report 93. Cambride, MA: The MIT Press. (

  • The Promoter of the Mouse M71 Odorant Receptor.

A. Rothman, P. Feinstein, J. Hirota, and P. Mombaerts. (2005). Mol. Cell. Neurosci. 28: 535– 546

  • Axon Guidance of Mouse Olfactory Sensory Neurons by Odorant Receptors

and The β2 Adrenergic Receptor.

P. Feinstein, T. Bozza, I. Rodriguez, A. Vassalli, and P. Mombaerts (2004). Cell 117: 833-846

  • A Contextual Model for Axonal Sorting into Glomeruli of the Mouse Olfactory System.

P. Feinstein and P. Mombaerts (2004). Cell 117: 817-831

  • Minigenes Impart Odorant Receptor-Specific Axon Guidance in the Olfactory Bulb.

A.Vassalli, A. Rothman, P. Feinstein, M. Zapotocky and P. Mombaerts (2002). Neuron 35: 681-696

  • Local Permutations in Glomerular Array of the Mouse Olfactory Bulb.

J. Strotmann, S. Conzelmannn, A. Beck, P. Feinstein, H. Breer and P. Mombaerts (2000). Journal of Neuroscience 20(18): 6927-6938

  • Identification of Homeotic Target Genes in Drosophila melanogaster

Including nervy, a Proto-Oncogene Homologue. P.G. Feinstein, K. Kornfeld, D. S. Hogness and R. S. Mann (1995). Genetics 140:573-586

  • Molecular Cloning and Biochemical Characterization of a Ca++/Calmodulin Insensitive Adenylate Cyclase from Rat Brain.

P. G. Feinstein, K. Shrader, H. A. Bakalyar, W. J. Tang, J. Krupinski, A. G. Gilman, and R .R. Reed (1991). PNAS 88(22):10173-10177

  • Molecular Cloning of Odorant-Binding Protein: Member of a Ligand Carrier Family.

Pevsner, R.R. Reed, P.G. Feinstein, and S.H. Snyder(1988). Science 241:336-339

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