Atinvicitinib

Atinvicitinib

Clinical data
ATCvet code	QD11AH93 (WHO)
Identifiers
IUPAC name 1-[(3R,4S)-4-cyanooxan-3-yl]-3-[(2-fluoro-6-methoxypyridin-4-yl)amino]pyrazole-4-carboxamide
CAS Number	2169273-59-8
PubChem CID	135138184
ChemSpider	76784061
UNII	C238YE66P2
ChEMBL	ChEMBL4066193
Chemical and physical data
Formula	C16H17FN6O3
Molar mass	360.349 g·mol−1
3D model (JSmol)	Interactive image
SMILES COC1=NC(=CC(=C1)NC2=NN(C=C2C(=O)N)[C@H]3COCC[C@@H]3C#N)F
InChI InChI=1S/C16H17FN6O3/c1-25-14-5-10(4-13(17)21-14)20-16-11(15(19)24)7-23(22-16)12-8-26-3-2-9(12)6-18/h4-5,7,9,12H,2-3,8H2,1H3,(H2,19,24)(H,20,21,22)/t9-,12+/m1/s1 Key:PRQMBGDYXWVEHE-SKDRFNHKSA-N

Atinvicitinib is a veterinary medicinal product under investigation for the treatment of atopic dermatitis in dogs. Atinvicitinib is a selective Janus kinase (JAK) inhibitor, highly selective for Janus kinase 1 (JAK1). It inhibits the function of a variety of cytokines involved in itch and inflammation, as well as cytokines involved in allergy, that are dependent on JAK1 enzyme activity. Reduction of allergy mediated inflammation, which is dependent on JAK1 enzyme activity, leads to a reduction of inflammation associated white blood cell counts (within the reference range).

Society and culture

Legal status

In June 2025, the Committee for Veterinary Medicinal Products of the European Medicines Agency adopted a positive opinion, recommending the granting of a marketing authorization for the veterinary medicinal product Numelvi, tablets, intended for dogs. The applicant for this veterinary medicinal product is Intervet International B.V.

Names

Atinvicitinib is the international nonproprietary name.