Coprococcus
| Coprococcus | |
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| Genus: | Coprococcus Holdeman and Moore 1974[1]
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| Type species | |
| Coprococcus eutactus Holdeman and Moore 1974
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Coprococcus is a genus of obligately anaerobic, nonmotile, Gram-positive cocci that are part of the human and animal gut microbiota.[2]
Coprococcus spp. are notable for their ability to ferment dietary fibers into short-chain fatty acids, especially butyrate, which is a key metabolite that supports colonocyte health, enhances mucosal integrity, and has anti-inflammatory properties. The genus is considered an important contributor to colonic homeostasis and overall gut health.[3]
Depletion of Coprococcus has been reported in patients with colorectal cancer, although a direct protective role remains to be fully established.[4]
One species, Coprococcus comes, may also influence the efficacy of blood pressure-lowering medications by modifying gut metabolism of esterified angiotensin-converting enzyme (ACE) inhibitors.[5]
Phylogeny
[edit]The currently accepted taxonomy is based on the List of Prokaryotic names with Standing in Nomenclature (LPSN)[1] and the National Center for Biotechnology Information (NCBI)[6]
| 16S rRNA-based LTP_10_2024[7][8][9] | 120 marker gene-based GTDB 09-RS220[10][11][12] | ||||||||||||||||||||||||
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Additional species placed elsewhere in LTP and GTDB phylogenies:
- Coprococcus catus Holdeman and Moore 1974
- Coprococcus comes Holdeman and Moore 1974
- "Coprococcus phoceensis" Bonnet et al. 2019
Etymology
[edit]From Ancient Greek:
- kopros – excrement, faeces
- kokkos – berry
→ Coprococcus – faecal coccus
See also
[edit]References
[edit]- ^ a b A.C. Parte; et al. "Coprococcus". List of Prokaryotic names with Standing in Nomenclature (LPSN). Retrieved 2022-09-09.
- ^ Holdeman, L. V.; Moore, W. E. C. (1974). "New Genus, Coprococcus, Twelve New Species, and Emended Descriptions of Four Previously Described Species of Bacteria from Human Feces". International Journal of Systematic Bacteriology. 24 (2): 260–277. doi:10.1099/00207713-24-2-260.
- ^ Louis, Petia; Flint, Harry J. (2017). "Formation of propionate and butyrate by the human colonic microbiota". Environmental Microbiology. 19 (1): 29–41. doi:10.1111/1462-2920.13589. PMID 27235414.
- ^ Xia, Li C.; Liu, Gang; Gao, Yingxin; Li, Xiaoxin; Pan, Hongfei; Ai, Dongmei (2019). "Identifying Gut Microbiota Associated With Colorectal Cancer Using a Zero-Inflated Lognormal Model". Frontiers in Microbiology. 10: 826. doi:10.3389/fmicb.2019.00826. ISSN 1664-302X. PMC 6491826. PMID 31068913.
- ^ Yang et al. (2022). Identification of a gut commensal that compromises the blood pressure-lowering effect of ester angiotensin-converting enzyme inhibitors. https://doi.org/10.1161/HYPERTENSIONAHA.121.18711. Hypertension. 2022;79:1591–1601.
- ^ Sayers; et al. "Coprococcus". National Center for Biotechnology Information (NCBI) taxonomy database. Retrieved 2022-09-09.
- ^ "The LTP". Retrieved 10 December 2024.
- ^ "LTP_all tree in newick format". Retrieved 10 December 2024.
- ^ "LTP_10_2024 Release Notes" (PDF). Retrieved 10 December 2024.
- ^ "GTDB release 09-RS220". Genome Taxonomy Database. Retrieved 10 May 2024.
- ^ "bac120_r220.sp_labels". Genome Taxonomy Database. Retrieved 10 May 2024.
- ^ "Taxon History". Genome Taxonomy Database. Retrieved 10 May 2024.