Jump to content

Draft:Min Han

From Wikipedia, the free encyclopedia

Min Han (born 1956) is a Chinese American geneticist and molecular biologist at the University of Colorado Boulder.

Early life and education

[edit]

Han was born in Shanghai, China. In 1977, after the death of Mao Zedong, the examination-based college entrance program was re-established, allowing Han to attend Peking University and receive his BS degree in Biochemistry. His strong academic performance secured a spot for him in the newly formed China-United States Biochemistry Examination and Application (CUSBEA) program (founded in 1982 by Professor Ray Wu of Cornell University and Professor Gu Xiaochen of Peking University) that connected rising Chinese students with Ph.D. programs in the US.[1] Han joined the lab of Dr. Michael Grunstein at UCLA and completed his Ph.D. in Molecular Biology. He then completed his postdoctoral training in the lab of Dr. Paul Sternberg at CalTech where he studied Developmental Genetics. He opened his own research lab at the University of Colorado Boulder in 1991, where he took a unique approach to research science and training.[2][3] He was awarded the title of Distinguished Professor in 2019.[4]

Research

[edit]

Han's graduate mentor was Dr. Michael Grunstein. Dr. Grunstein was awarded the prestigious Lasker Award in 2018; Han's 1988 Cell paper[5] from the Grunstein lab was listed as a key publication for the award.[6]

Han's postdoctoral advisor was Dr. Paul Sternberg. In the Sternberg lab, Han discovered the C. elegans ras gene let-60 (Han & Sternberg 1990, Cell)[7][8][9]

Discoveries made in the Min Han Lab at the University of Colorado:

  • Discovered and analyzed the roles of regulators of the conserved RTK-RAS-MPK signaling pathway; discovered many unknown roles of tumor suppressors in development and stress responses.[10][11]
  • Established the concept of universal pairing of SUN-KASH proteins (LINC complexes) at the nuclear envelope and pioneered the study of their functions in multiple cellular/developmental events in both C. elegans and mice.[12][13][14][15]
  • Discovered the role of GW182 family proteins in miRISCs and a pioneered biochemical method to systematically analyze the in vivo miRNA-target interactions; discovered miRNA-like regulatory function for apoptotic caspases.[16][17][18][19]
  • Uncovered novel functions of fatty acid variants and multiple novel mechanisms by which animals sense the level of specific fatty acids and nucleotides to regulate animal development and behaviors.[20][21][22][23][24]
  • Discovered "surprising" beneficial roles for two bacteria-derived molecules in animal physiology that indicates new paradigms pertinent to microbe-host interactions (enterobactin and peptidoglycan muropeptides).[25][26][27][28][29]

Recognition and awards

[edit]

References

[edit]
  1. ^ Chang, Zengyi (2009). "The CUSBEA program: Twenty years after". IUBMB Life. 61 (6): 555–565. doi:10.1002/iub.218. ISSN 1521-6551. PMID 19472190.
  2. ^ Han, Min (2015-11-01). "Twists and turns—How we stepped into and had fun in the "boring" lipid field". Science China Life Sciences. 58 (11): 1073–1083. doi:10.1007/s11427-015-4949-6. ISSN 1869-1889. PMID 26511515.
  3. ^ Gates, Leah; Weaver, Benjamin P. (2025-04-21). "Career pathways, part 17". Nature Metabolism: 1–4. doi:10.1038/s42255-025-01288-9. ISSN 2522-5812. PMID 40259048.
  4. ^ "4 CU Boulder faculty members become distinguished professors | CU Boulder Today | University of Colorado Boulder". www.colorado.edu. Retrieved 2025-05-27.
  5. ^ Han, Min; Grunstein, Michael (1988-12-23). "Nucleosome loss activates yeast downstream promoters in vivo". Cell. 55 (6): 1137–1145. doi:10.1016/0092-8674(88)90258-9. ISSN 0092-8674. PMID 2849508.
  6. ^ Admin, Lasker. "Histone modifications and gene expression". Lasker Foundation. Retrieved 2025-05-27.
  7. ^ Han, Min; Sternberg, Paul W. (1990-11-30). "let-60, a gene that specifies cell fates during C. elegans vulval induction, encodes a ras protein". Cell. 63 (5): 921–931. doi:10.1016/0092-8674(90)90495-Z. ISSN 0092-8674. PMID 2257629.
  8. ^ Greenwald, Iva; Broach, James R. (1990-12-21). "Cell fates in C. elegans: In medias ras". Cell. 63 (6): 1113–1116. doi:10.1016/0092-8674(90)90403-2. ISSN 0092-8674. PMID 2261634.
  9. ^ Bourne, Henry R.; Sanders, David A.; McCormick, Frank (November 1990). "The GTPase superfamily: a conserved switch for diverse cell functions". Nature. 348 (6297): 125–132. Bibcode:1990Natur.348..125B. doi:10.1038/348125a0. ISSN 1476-4687. PMID 2122258.
  10. ^ Downward, Julian (1995-12-15). "KSR: A novel player in the RAS pathway". Cell. 83 (6): 831–834. doi:10.1016/0092-8674(95)90198-1. ISSN 0092-8674. PMID 8521506.
  11. ^ Sternberg, Paul W.; Alberola-Ila, José (1998-11-13). "Conspiracy Theory: RAS and RAF Do Not Act Alone". Cell. 95 (4): 447–450. doi:10.1016/S0092-8674(00)81612-8. ISSN 0092-8674. PMID 9827797.
  12. ^ Ruegg, Markus A. (2005-04-19). "Organization of synaptic myonuclei by Syne proteins and their role during the formation of the nerve–muscle synapse". Proceedings of the National Academy of Sciences. 102 (16): 5643–5644. Bibcode:2005PNAS..102.5643R. doi:10.1073/pnas.0501516102. PMC 556304. PMID 15827115.
  13. ^ Pentimalli, Francesca (July 2007). "Helping homologues to find their partners". Nature Reviews Genetics. 8 (7): 493. doi:10.1038/nrg2154. ISSN 1471-0064.
  14. ^ Koizumi, Hiroyuki; Gleeson, Joseph G. (2009-10-29). "Sun Proteins Enlighten Nuclear Movement in Development". Neuron. 64 (2): 147–149. doi:10.1016/j.neuron.2009.10.010. ISSN 0896-6273. PMC 4340071. PMID 19874779.
  15. ^ Starr, Daniel A. (2012-09-11). "Laminopathies: Too Much SUN Is a Bad Thing". Current Biology. 22 (17): R678 – R680. Bibcode:2012CBio...22.R678S. doi:10.1016/j.cub.2012.06.070. ISSN 0960-9822. PMC 4090695. PMID 22974992.
  16. ^ Stevens, Katherine (February 2008). "Gathering a bouquet of miRNA targets". Nature Methods. 5 (2): 123. doi:10.1038/nmeth0208-122b. ISSN 1548-7105.
  17. ^ Aguirre-Chen, Cristina; Hammell, Christopher M (2014-12-30). "Cell death machinery makes life more robust". eLife. 3: e05816. doi:10.7554/eLife.05816. ISSN 2050-084X. PMC 4279077. PMID 25549297.
  18. ^ Conradt, Barbara (2017-06-19). "Partners in Crime". Developmental Cell. 41 (6): 573–574. doi:10.1016/j.devcel.2017.06.002. ISSN 1534-5807. PMID 28633011.
  19. ^ Yarychkivska, Olya; Shaham, Shai (2020-05-04). "Development or Disease: Caspases Balance Growth and Immunity in C. elegans". Developmental Cell. 53 (3): 259–260. doi:10.1016/j.devcel.2020.04.006. ISSN 1534-5807. PMID 32369740.
  20. ^ "In roundworms, fats tip the scales of fertility | CU Boulder Today | University of Colorado Boulder". www.colorado.edu. Retrieved 2025-05-27.
  21. ^ VanHook, Annalisa M. (2008-08-12). "Fatty Acid-Regulated Diapause". Science Signaling. 1 (32): ec289. doi:10.1126/scisignal.132ec289.
  22. ^ Vrablik, Tracy L.; Watts, Jennifer L. (2012-04-01). "Emerging roles for specific fatty acids in developmental processes". Genes & Development. 26 (7): 631–637. doi:10.1101/gad.190777.112. ISSN 0890-9369. PMC 3323873. PMID 22474257.
  23. ^ Shi, Cheng; Murphy, Coleen T. (2016-02-01). "Feeding the germline". Genes & Development. 30 (3): 249–250. doi:10.1101/gad.276980.115. ISSN 0890-9369. PMC 4743054. PMID 26833726.
  24. ^ VanHook, Annalisa M. (2016-02-09). "Notch for nucleotide sensing". Science Signaling. 9 (414): ec27. doi:10.1126/scisignal.aaf4220.
  25. ^ "The unexpected upside of E. coli | CU Boulder Today | University of Colorado Boulder". www.colorado.edu. Retrieved 2025-05-27.
  26. ^ "How the E. coli Bacterium Can Benefit Us | Microbiology". Labroots. Retrieved 2025-05-27.
  27. ^ Boulder, University of Colorado at. "E. coli bacterium key for boosting iron absorption, new study shows". phys.org. Retrieved 2025-05-27.
  28. ^ Kim, Dennis H. (2018-10-04). "Bacterial Siderophores Promote Animal Host Iron Acquisition and Growth". Cell. 175 (2): 311–312. doi:10.1016/j.cell.2018.09.020. ISSN 0092-8674. PMID 30290138.
  29. ^ Anderson, Gregory J. (2018-11-22). "Iron Wars — The Host Strikes Back". New England Journal of Medicine. 379 (21): 2078–2080. doi:10.1056/NEJMcibr1811314. ISSN 0028-4793. PMID 30462940.
  30. ^ "Min Han | American Academy of Arts and Sciences". www.amacad.org. 2025-05-19. Retrieved 2025-05-27.
  31. ^ "3 CU Boulder professors named American Academy of Arts and Sciences members | CU Boulder Today | University of Colorado Boulder". www.colorado.edu. Retrieved 2025-05-27.
  32. ^ "4 CU Boulder faculty members become distinguished professors | CU Boulder Today | University of Colorado Boulder". www.colorado.edu. Retrieved 2025-05-27.
  33. ^ "Min Han, PhD | Former Investigator Profile | 1997-2018". www.hhmi.org. Retrieved 2025-05-27.
  34. ^ "Searle Scholars Program", Wikipedia, 2025-05-17, retrieved 2025-05-27
  35. ^ Read "Evaluation of the Markey Scholars Program" at NAP.edu. 2006. doi:10.17226/11755. ISBN 978-0-309-10292-6.
  36. ^ "Alumni Fellows". Life Sciences Research Foundation. Retrieved 2025-05-27.
Retrieved from "https://en.wikipedia.org/w/index.php?title=Draft:Min_Han&oldid=1292749316"