Flavonifractor plautii
| Flavonifractor plautii | |
|---|---|
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Scientific classification 
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| Domain: | Bacteria |
| Kingdom: | Bacillati |
| Phylum: | Bacillota |
| Class: | Clostridia |
| Order: | Oscillospirales |
| Family: | Oscillospiraceae |
| Genus: | Flavonifractor |
| Species: | F. plautii
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| Binomial name | |
| Flavonifractor plautii (Séguin 1928) Carlier et al. 2010[1]
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| Synonyms | |
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Flavonifractor plautii is a bacterium of the monotypic genus Flavonifractor in the family Oscillospiraceae.
History
[edit]This species was originally placed in the genus Fusobacterium by S. Seguin in 1928,[2] and was later recategorized as Fusocillus in 1938 by A.R. Prevot.[3] This classification remained until 1962, when M. Sebald renamed the species Zuberella plauti.[4] In 1928, Skerman VBD and colleagues referred to this species as Fusobacterium plauti in the “Approved Lists of Bacterial Names”.[5] In 1982, Hofstad and Aasjord officially assigned the name Eubacterium plautii to this species.[6] In 1991, Winter et al. highlighted the bacterium’s ability to cleave flavonoids and introduced its basionym as Clostridium orbiscindens.[7] Finally, in 2010, Carlier et al. proposed the unification of Clostridium orbiscindens and Eubacterium plautii under the new name Flavonifractor plautii. The cells are described as straight or slightly curved rods, 2–10 microns long, occurring singly or in pairs. Strains have been isolated from human feces, blood, intra-abdominal pus, and infected soft tissues.[8]
Genome
[edit]Flavonifractor plautii has a genome consisting of a single circular chromosome with 3,985,392 base pairs, with a G+C content of 60.9%. The genome is predicted to contain 3 complete sets of rRNA genes, 63 tRNA genes, and 3,764 protein-coding sequences.[9]
Metabolism and ecology
[edit]This bacterium is an obligate anaerobe that is capable of cleaving the C-ring found in flavonoids. Flavonifractor plautii is highly prevalent in the human gastrointestinal tract, and is known to be a proficient producer of butyrate.[10]
Clinical significance
[edit]Flavonifractor plautii was found to be associated with colorectal cancer (CRC) in a cohort of 30 CRC patients and 30 healthy controls. It was hypothesized that the degradation of beneficial anticarcinogenic flavonoids, such as quercetin, by F. plautii may contribute to the cancer.[11] Flavonifractor plautii was also found to be significantly enriched in major depressive disorder (MDD) in a cohort of 90 American young adults (43 with MDD, 47 healthy).
In pediatric inflammatory bowel disease, F. plautii was shown to preferentially bind immunoglobulin G (IgG) from Crohn’s disease patients compared to non-inflammatory bowel disease and ulcerative colitis samples. It also demonstrated invasive potential in vitro using a fluorescence microscopy assay with intestinal epithelial cells in culture.[12]
References
[edit]- ^ a b Page Species: Flavonifractor plautii on "LPSN - List of Prokaryotic names with Standing in Nomenclature". Deutsche Sammlung von Mikroorganismen und Zellkulturen. Retrieved 2022-10-03.
- ^ du Bois P (May 2003). "Sur la forme de Seifert entière des germes de courbe plane à deux branches". Comptes Rendus Mathematique. 336 (9): 757–762. doi:10.1016/s1631-073x(03)00165-1. ISSN 1631-073X.
- ^ Williams P (2017). "Le Pasteur Matéo". Études Tsiganes. 60 (1): 142. doi:10.3917/tsig.060.0142. ISSN 0014-2247.
- ^ Pichinoty F (October 1962). "Inhibition par l'oxygene de la biosynthese et de l'activitee de l'hydrogenase et de l'hydrogenelyase chez les bacteries anaerobies facultatives". Biochimica et Biophysica Acta. 64 (1): 111–124. doi:10.1016/0006-3002(62)90764-3. ISSN 0006-3002. PMID 13943284.
- ^ Skerman VB, Sneath PH, McGowan V (1980-01-01). "Approved Lists of Bacterial Names". International Journal of Systematic and Evolutionary Microbiology. 30 (1): 225–420. doi:10.1099/00207713-30-1-225. ISSN 1466-5026.
- ^ Hofstad T, Aasjor P (1982-07-01). "Eubacterium plautii (Seguin 1928) comb. nov". International Journal of Systematic Bacteriology. 32 (3): 346–349. doi:10.1099/00207713-32-3-346. ISSN 0020-7713.
- ^ Winter J, Popoff MR, Grimont P, Bokkenheuser VD (1991-07-01). "Clostridium orbiscindens sp. nov., a Human Intestinal Bacterium Capable of Cleaving the Flavonoid C-Ring". International Journal of Systematic Bacteriology. 41 (3): 355–357. doi:10.1099/00207713-41-3-355. ISSN 0020-7713. PMID 1883711.
- ^ Carlier JP, Bedora-Faure M, K'ouas G, Alauzet C, Mory F (2010-03-01). "Proposal to unify Clostridium orbiscindens Winter et al. 1991 and Eubacterium plautii (Séguin 1928) Hofstad and Aasjord 1982, with description of Flavonifractor plautii gen. nov., comb. nov., and reassignment of Bacteroides capillosus to Pseudoflavonifractor capillosus gen. nov., comb. nov". International Journal of Systematic and Evolutionary Microbiology. 60 (Pt 3): 585–590. doi:10.1099/ijs.0.016725-0. ISSN 1466-5026. PMID 19654357.
- ^ Tourlousse DM, Sakamoto M, Miura T, Narita K, Ohashi A, Uchino Y, et al. (2020-04-23). Rasko D (ed.). "Complete Genome Sequence of Flavonifractor plautii JCM 32125 T". Microbiology Resource Announcements. 9 (17): e00135–20. doi:10.1128/MRA.00135-20. ISSN 2576-098X. PMC 7180276. PMID 32327522. S2CID 216110981.
- ^ Rajilić-Stojanović M, de Vos WM (September 2014). "The first 1000 cultured species of the human gastrointestinal microbiota". FEMS Microbiology Reviews. 38 (5): 996–1047. doi:10.1111/1574-6976.12075. ISSN 1574-6976. PMC 4262072. PMID 24861948.
- ^ Gupta A, Dhakan DB, Maji A, Saxena R, PK VP, Mahajan S, et al. (2019-12-17). Bordenstein S (ed.). "Association of Flavonifractor plautii, a Flavonoid-Degrading Bacterium, with the Gut Microbiome of Colorectal Cancer Patients in India". Msystems. 4 (6): e00438–19. doi:10.1128/mSystems.00438-19. ISSN 2379-5077. PMC 7407896. PMID 31719139.
- ^ Armstrong H, Alipour M, Valcheva R, Bording-Jorgensen M, Jovel J, Zaidi D, et al. (December 2019). "Host immunoglobulin G selectively identifies pathobionts in pediatric inflammatory bowel diseases". Microbiome. 7 (1): 1. doi:10.1186/s40168-018-0604-3. ISSN 2049-2618. PMC 6317230. PMID 30606251.
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