Lello Zolla
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Lello Zolla | |
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| Born | 1948 |
| Citizenship |  Italy |
| Known for | Proteomics, Metabolomics, Chromatography, mass spectrometry |
| Scientific career | |
| Institutions | University of Tuscia, University of Camerino, Sapienza University of Rome |
Lello Zolla (born 1948) is an Italian professor of molecular biology and researcher. He is known for his work in proteomics and metabolomics, particularly using mass spectrometry and chromatography.[1]
Academic career
[edit]Zolla began his research in 1974 at the Sapienza University of Rome under the mentorship of Emo Antonio Antonini and Maurizio Brunori, focusing on allosteric mechanisms in respiratory proteins such as hemoglobin and hemocyanin.[2] In 1986, he became a full professor of biochemistry at the University of Camerino, where he directed the High School of Chemistry and Clinical Biochemistry until 1991.
In the late 1990s, his research shifted to plant proteomics and the effects of heavy metals on plant metabolism, using two-dimensional gels and capillary electrophoresis.[3]
Since 2005, Zolla's group has developed chromatographic methods such as nanoLC and 2D-LC coupled with mass spectrometry for use in omics-based studies.[4]
Scientific activity
[edit]Zolla is a member of the editorial board of the Journal of Proteomics, an academic journal in the field of proteomics.[5]
Supported by the Italian National Blood Centre, his lab conducted proteomic and metabolomic studies on red blood cells to investigate storage-related protein damage and propose alternative preservation methods.[6]
In a collaborative study, Zolla's team analyzed the urinary metabolome of young autistic children in Italy, identifying metabolic alterations with diagnostic potential.[7]
He has also contributed to endocrinological research, including the metabolic effects of testosterone therapy in patients with male hypogonadism.[8]
Selected publications
[edit]- Premstaller A., Timperio A. M., Zolla L., et al. "High‑Performance Liquid Chromatography–Electrospray Ionization Mass Spectrometry Using Monolithic Capillary Columns for Proteomic Studies". *Analytical Chemistry*, 2001. [1]
- Timperio A. M., Egidi M. G., Zolla L., et al. "Proteomics Applied on Plant Abiotic Stresses". *Journal of Proteomics*, 2008. [2]
- D'Alessandro A., Zolla L. "Proteomics for Quality‑Control Processes in Transfusion Medicine". *Analytical and Bioanalytical Chemistry*, 2010. [3]
- Gevi F., Zolla L., Gabriele S., Persico A. M. "Urinary Metabolomics of Young Italian Autistic Children". *Molecular Autism*, 2016. [4]
External links
[edit]References
[edit]- ^ "Lello Zolla – Google Scholar". Retrieved 10 June 2025.
- ^ Brunori, Maurizio (1975). "Allosteric transitions in hemoglobin". Acc. Chem. Res. 8 (12): 448–454. doi:10.1021/ar50097a003.
- ^ Timperio, A.M.; Zolla, L. (2008). "Proteomics Applied on Plant Abiotic Stresses". Journal of Proteomics. 71 (4): 391–411. doi:10.1016/j.jprot.2008.07.005. PMID 18718564.
- ^ Premstaller, A.; Zolla, L. (2001). "High‑Performance Liquid Chromatography–Electrospray Ionization Mass Spectrometry Using Monolithic Capillary Columns for Proteomic Studies". Analytical Chemistry. 73 (11): 2390–2396. doi:10.1021/ac010046q. PMID 11403277.
- ^ "Journal of Proteomics – Editorial Board". Retrieved 10 June 2025.
- ^ D'Alessandro, A.; Zolla, L. (2010). "Proteomics for Quality‑Control Processes in Transfusion Medicine". Analytical and Bioanalytical Chemistry. 398 (1): 111–124. doi:10.1007/s00216-010-3799-0. PMID 20496175.
- ^ Gevi, F.; Zolla, L.; Gabriele, S.; Persico, A.M. (2016). "Urinary Metabolomics of Young Italian Autistic Children Supports Abnormal Tryptophan and Purine Metabolism". Molecular Autism. 7: 47. doi:10.1186/s13229-016-0109-5. PMC 5121959. PMID 27904735.
- ^ Gacci, M.; Zolla, L. (2022). "Testosterone replacement therapy in male hypogonadism and metabolic impact". Andrology Reports. 5: 101–112.
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