NKG7

NKG7
Identifiers
Aliases	NKG7, GIG1, GMP-17, p15-TIA-1, natural killer cell granule protein 7
External IDs	OMIM: 606008; MGI: 1931250; HomoloGene: 4092; GeneCards: NKG7; OMA:NKG7 - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	51,372,701 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	43,087,673 bp
RNA expression pattern
	Top expressed in
	granulocyte; ; testicle; ; blood; ; bone marrow; ; spleen; ; bone marrow cells; ; mononuclear cell; ; monocyte; ; trabecular bone; ; lymph node;
	Top expressed in
	tibiofemoral joint; ; blood; ; mesenteric lymph nodes; ; granulocyte; ; spleen; ; embryo; ; thymus; ; bone marrow; ; intestinal villus; ; gastrula;
	More reference expression data
	n/a
Orthologs
	4818
	72310
	ENSG00000105374
	ENSMUSG00000004612
	Q16617
	Q99PA5
	NM_005601; NM_001363693
	NM_024253
	NP_005592; NP_001350622
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Natural killer cell granule protein 7 (NKG7 protein) is a protein that in humans is encoded by the NKG7 gene. ^[5] The protein is under study regarding potential in cancer research into T cell activity.^[6] A role of the NKG7 protein in regulating cell resistance and fighting tumors in certain types of cancer is being studied because of its ability to recognize and kill cancer cells through CD8+ T cell resilience that is essential for anti-tumor activity. The research suggests that the NKG7 protein allows the CD8+ T cells to continue killing malignant cells in certain circumstances and may prevent growth and metastasis of the malignant cells being attacked by the CD8+ T cells.

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000105374 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000004612 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: Natural killer cell granule protein 7". Retrieved 2016-02-23.
^ Gallagher, Colette, Mayo Clinic discovers new role for protein to fight tumors, Mayo Clinic, February 27, 2025

References

Further reading