β-Keto-N-methylphenethylamine

β-Keto-N-methylphenethylamine
Clinical data
Other names	βk-NMPEA; FTS-096; FTS096; Methylaminoacetophenone; 2-(Methylamino)acetophenone; NM-AcP; MAA
Drug class	Norepinephrine–dopamine releasing agent
Identifiers
	IUPAC name 2-(methylamino)-1-phenylethanone;
CAS Number	35534-19-1;
PubChem CID	416157;
ChemSpider	368424;
ChEMBL	ChEMBL1907015;
CompTox Dashboard (EPA)	DTXSID70328985 ;
Chemical and physical data
Formula	C9H11NO
Molar mass	149.193 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CNCC(=O)C1=CC=CC=C1;
	InChI InChI=1S/C9H11NO/c1-10-7-9(11)8-5-3-2-4-6-8/h2-6,10H,7H2,1H3; Key:VVFCJVLORNFVHI-UHFFFAOYSA-N;

β-Keto-N-methylphenethylamine (βk-NMPEA), also known as FTS-096, is a monoamine releasing agent of the phenethylamine family.^[1]^[2]^[3] It is the N-methyl analogue of phenacylamine (β-ketophenethylamine or α-desmethylcathinone) and the β-keto analogue of N-methylphenethylamine.^[1]^[2]^[3] The drug acts as a norepinephrine–dopamine releasing agent (NDRA), with EC₅₀Tooltip half-maximal effective concentration values for induction of monoamine release of 148 nM for norepinephrine, 1,860 nM for dopamine, and >60,000 nM for serotonin in rat brain synaptosomes.^[1]^[2]^[3] βk-NMPEA was first described in the scientific literature by 2019.^[1]^[2]^[3]

References

^ ^a ^b ^c ^d Davies RA, Baird TR, Nguyen VT, Ruiz B, Sakloth F, Eltit JM, et al. (June 2020). "Investigation of the Optical Isomers of Methcathinone, and Two Achiral Analogs, at Monoamine Transporters and in Intracranial Self-Stimulation Studies in Rats". ACS Chemical Neuroscience. 11 (12): 1762–1769. doi:10.1021/acschemneuro.9b00617. PMC 10019599. PMID 32356961.
^ ^a ^b ^c ^d Nguyen V (2019). Analyzing Interactions Between Methcathinone Analogs and the Human Monoamine Transporters. Theses and Dissertations (Master of Science thesis). Virginia Commonwealth University. doi:10.25772/T1DW-MG60 – via VCU Scholars Compass.
^ ^a ^b ^c ^d Davies RA (10 July 2019). Structure-Activity Relationship Studies of Synthetic Cathinones and Related Agents. Theses and Dissertations (Doctor of Philosophy thesis). Virginia Commonwealth University. doi:10.25772/TZSA-0396. Retrieved 24 November 2024 – via VCU Scholars Compass.

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