Rezuforimod

Rezuforimod
Identifiers
	IUPAC name 2-{[(2S)-2-[(4-bromophenyl)carbamoylamino]-4-methylpentanoyl]amino}acetic acid;
CAS Number	1431754-15-2;
PubChem CID	71526099;
ChEMBL	ChEMBL4785302;
Chemical and physical data
Formula	C15H20BrN3O4
Molar mass	386.246 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CC(C)C[C@@H](C(=O)NCC(=O)O)NC(=O)NC1=CC=C(C=C1)Br;
	InChI InChI=1S/C15H20BrN3O4/c1-9(2)7-12(14(22)17-8-13(20)21)19-15(23)18-11-5-3-10(16)4-6-11/h3-6,9,12H,7-8H2,1-2H3,(H,17,22)(H,20,21)(H2,18,19,23)/t12-/m0/s1; Key:LASJSIMHDHTROE-LBPRGKRZSA-N;

Rezuforimod is an experimental drug that acts as a potent and selective agonist of formyl peptide receptor 2 with an EC₅₀ of 0.88nM, which inhibits neutrophil adhesion and has antiinflammatory effects.^[1]^[2]

References

^ Maciuszek M, Cacace A, Brennan E, Godson C, Chapman TM (March 2021). "Recent advances in the design and development of formyl peptide receptor 2 (FPR2/ALX) agonists as pro-resolving agents with diverse therapeutic potential". European Journal of Medicinal Chemistry. 213: 113167. doi:10.1016/j.ejmech.2021.113167. PMID 33486199.
^ Maciuszek M, Ortega-Gomez A, Maas SL, Perretti M, Merritt A, Soehnlein O, et al. (March 2021). "Synthesis and evaluation of novel cyclopentane urea FPR2 agonists and their potential application in the treatment of cardiovascular inflammation". European Journal of Medicinal Chemistry. 214: 113194. doi:10.1016/j.ejmech.2021.113194. PMID 33548634.