S9632

S9632
Identifiers
	IUPAC name 4-amino-5-[2,2-dimethyl-3-oxo-3-(propan-2-ylamino)propoxy]-2-methylquinoline-3-carboxylic acid;
CAS Number	1359963-68-0;
PubChem CID	66746559;
ChemSpider	28475396;
UNII	QCE6H7E9VS;
ChEMBL	ChEMBL4561660;
Chemical and physical data
Formula	C19H25N3O4
Molar mass	359.426 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CC1=C(C(=C2C(=N1)C=CC=C2OCC(C)(C)C(=O)NC(C)C)N)C(=O)O;
	InChI InChI=1S/C19H25N3O4/c1-10(2)21-18(25)19(4,5)9-26-13-8-6-7-12-15(13)16(20)14(17(23)24)11(3)22-12/h6-8,10H,9H2,1-5H3,(H2,20,22)(H,21,25)(H,23,24); Key:RHXLOOCFQPJWBW-UHFFFAOYSA-N;

S9632 (FEMA 4774) is a food additive which acts as a positive allosteric modulator of the TAS1R2/TAS1R3 heterodimer that is the primary sweet taste receptor in humans. It is described as a flavour modifier, having little taste of its own but causing sweet flavours to taste sweeter and enhancing certain aspects of the flavour profile. It was approved for use in food in 2012 and is used in various countries including the United States, Japan, South Korea, and Mexico.^[1]^[2]

References

^ Arthur AJ, Karanewsky DS, Liu H, Chi B, Markison S (2015). "Toxicological evaluation of the flavour ingredient 4-amino-5-(3-(isopropylamino)-2,2-dimethyl-3-oxopropoxy)-2-methylquinoline-3-carboxylic acid". Toxicology Reports. 2: 1255–1264. Bibcode:2015ToxR....2.1255A. doi:10.1016/j.toxrep.2015.08.012. PMC 5598146. PMID 28962468.
^ Chéron JB, Soohoo A, Wang Y, Golebiowski J, Antonczak S, Jiang P, et al. (May 2019). "Conserved Residues Control the T1R3-Specific Allosteric Signaling Pathway of the Mammalian Sweet-Taste Receptor". Chemical Senses. 44 (5): 303–310. doi:10.1093/chemse/bjz015. PMC 6538948. PMID 30893427.

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[1] Arthur AJ, Karanewsky DS, Liu H, Chi B, Markison S (2015). "Toxicological evaluation of the flavour ingredient 4-amino-5-(3-(isopropylamino)-2,2-dimethyl-3-oxopropoxy)-2-methylquinoline-3-carboxylic acid". Toxicology Reports. 2: 1255–1264. Bibcode:2015ToxR....2.1255A. doi:10.1016/j.toxrep.2015.08.012. PMC 5598146. PMID 28962468.

[2] Chéron JB, Soohoo A, Wang Y, Golebiowski J, Antonczak S, Jiang P, et al. (May 2019). "Conserved Residues Control the T1R3-Specific Allosteric Signaling Pathway of the Mammalian Sweet-Taste Receptor". Chemical Senses. 44 (5): 303–310. doi:10.1093/chemse/bjz015. PMC 6538948. PMID 30893427.

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[2]

See also

References