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Sourav Bhattacharjee

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Sourav Bhattacharjee
Born (1978-09-16) September 16, 1978 (age 46)
Kolkata, India
NationalityDutch
Academic background
EducationMBBS, Medical College Kolkata
MSc (Biomolecular Sciences), VU Amsterdam
PhD, Wageningen University
Alma materMedical College Kolkata
Vrije Universiteit Amsterdam
Wageningen University
Doctoral advisorHan Zuilhof; Gerrit Alink; Ivonne MCM Rietjens; Antonius TM Marcelis
Academic work
InstitutionsUniversity College Dublin

Sourav Bhattacharjee is a Dutch biomedical scientist and anatomist of Indian origin. He is a Professor in the Veterinary Biosciences section at the School of Veterinary Medicine, University College Dublin.[1]

Bhattacharjee is known for his work on comparative anatomy, biomedical imaging, and translational drug delivery systems. His works have been published in academic journals such as Journal of Controlled Release, Nanoscale, Small, Journal of Anatomy, and Annals of Anatomy.[2] Additionally, he edited the ‘’Special Issue on Biomedical Imaging in Comparative Anatomy’’ in the Journal of Anatomy.[3] He also co-invented an oral delivery system wherein he described methods to create stabilized silica-coated sub-micron particles of proteins or peptides, including GLP-1 agonists and insulin, using a basic compound, zinc, and orthosilicic acid.[4] Moreover, he was ranked among the top 2% of scientists by Elsevier for five consecutive years, from 2020 to 2024.[5][6]

Bhattacharjee is a fellow of the Royal Asiatic Society. Moreover, he is an editorial board member of several journals, including Nature Scientific Reports.[7]

Education

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Bhattacharjee completed his Bachelor of Medicine and Surgery (MBBS) from Medical College Kolkata (India) in 2004, followed by an MSc in Biomolecular Sciences in 2008 from the Vrije Universiteit Amsterdam (Netherlands). Later in 2012, he obtained his PhD from Wageningen University in the Netherlands.[1]

Career

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Bhattacharjee briefly served as a Residential House Surgeon at the Medical College Kolkata (India) in 2004. He also worked as a Student Assistant at the Lab of Organic Chemistry in 2008. From September 2012 to September 2013, he was a Post-Doctoral Researcher in the BIOS Lab-on-a-Chip group at the University of Twente (Netherlands). Between 2014 and 2016, he served as a Post-Doctoral Research Fellow at the School of Veterinary Medicine and the Conway Institute, University College Dublin. Additionally, between 2017 and 2019, he also served as an Honorary Demonstrator in Anatomy in the School of Medicine at Imperial College London (UK). Moreover, since 2016, he has been serving as an Assistant Professor in Veterinary Biosciences at the School of Veterinary Medicine, University College Dublin.[1]

Bhattacharjee is an active member of the Anatomical Society and has represented the society on various occasions, including initiatives to promote careers in anatomy[8] and participation in Anatomical Society conferences. He has delivered invited and keynote lectures internationally, with engagements in countries such as India, Indonesia, Spain,[9] and South Korea.[10] He has also been interviewed by academic journals in recognition of his expertise in nanomedicine.[11][12] Moreover, in 2024, he presented seminars on tissue autofluorescence and oral insulin delivery at the University of Tartu and the Estonian University of Life Sciences in Estonia.[13][14]

Research

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Bhattacharjee’s 2009 paper investigated the cytotoxicity of silicon nanoparticles with different surface functionalizations (amine, azide, carboxylic acid), imparting various surface charges, showing that positively charged silicon nanoparticles were more cytotoxic in vitro compared to the negatively charged ones, with serum presence influencing the toxicity.[15] Later, he examined how silicon nanoparticle surface charge affected cytotoxicity in macrophages, highlighting oxidative stress, mitochondrial involvement, and reactive oxygen species (ROS) production as key mechanisms of toxicity, with antioxidants providing protective effects.[16] Two years later, in 2012, he studied the effects of polymer nanoparticles' size and surface charge on cellular uptake, cytotoxicity, and the mechanisms of mitochondrial damage, reactive oxygen species production, and oxidative stress in different cell types.[17] In 2013, he investigated and compared the cytotoxicity of silicon and germanium nanoparticles, highlighting the impact of surface coatings, size, and doping on toxicity, particularly through mitochondrial dysfunction, with implications for bioimaging and biomedical applications.[18] In the same year, he explored the synthesis, cytotoxicity, cellular uptake, and interactions of polymeric nanoparticles with varying surface charges (cationic and anionic), emphasizing how surface charge and steric shielding of cationic charge influenced nanoparticle behavior and cytotoxicity under biological ambience.[19]

Subsequently, in 2014, Bhattacharjee investigated how surface charge and size of polystyrene nanoparticles affected cytotoxicity, focusing on oxidative stress and membrane disturbances as key mechanisms, particularly for cationic nanoparticles in macrophage cells.[20] His 2016 work reviewed dynamic light scattering and zeta potential techniques for nanoparticle characterization in drug delivery, explaining principles, challenges, and practical tips to help non-experts obtain reliable, relevant measurements.[21] Additionally, in 2017, he investigated how particle size, surface charge, and methyl-PEGylation affected the transport and interaction of silica nanoparticles with porcine jejunal mucus, providing insights for designing oral nanomedicines with improved mucopermeability.[22] In 2019, he edited the book Principles of Nanomedicine. The book explored nanomedicine, covering its history, fundamental properties of nanoscale materials, and applications in drug delivery, sensing, and imaging.[23] Later in 2020, he studied how ionic strength, pH, salt valency, and detergents affected the zeta potential and colloidal stability of extracellular vesicles derived from human choriocarcinoma JAr cells.[24] In the same year, he addressed burst release in drug delivery from nanocarriers, explored its causes, mathematical models, current mitigation techniques, and future directions for improving sustained release and translation into clinical applications.[25]

In 2023, Bhattacharjee authored a book chapter in Microscopy Techniques for Biomedical Education and Healthcare Practice, wherein he explored advanced microscopy and particle tracking techniques for studying cellular dynamics, focusing on nanoscale processes, biomedical applications, and the development of nanomedicines, while critiquing tracking software and future challenges.[26] More recently in 2024, he explored using machine learning on radiomics data from CT scans to predict grading and staging of upper tract urothelial carcinoma, offering potential for earlier, more accurate diagnoses compared to traditional methods.[27] Additionally, he also developed a predictive model combining radiomics from CT urograms and clinical data to accurately forecast survival and recurrence in UTUC patients, showing improved prognostic performance and achieving statistical significance in diagnosis.[28]

Directing his research efforts towards anatomy, Bhattacharjee examined the historical integration of humanistic values in anatomy, highlighting ethical challenges, legal responses, and lessons from past atrocities, shaping modern anatomical practices and promoting humane treatment in medicine.[29] Moreover, he also examined historical public dissections, highlighting their spiritual and societal roots, traced their decline due to ethical lapses, and advocated for renewed societal engagement through spiritually guided anatomical practices.[30] Among other things, he has worked on incorporating One Health principles into anatomy education and research, focusing on the relationships among human, animal, and environmental health.[31] This work examined how these interconnections can inform understandings of health and disease. Additionally, he is affiliated with the UCD One Health Centre and has published on topics related to One Health.[32]

Bibliography

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Book

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  • Principles of Nanomedicine. Jenny Stanford Publishing. 2019. ISBN 9789814800426.

Selected articles

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References

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  1. ^ a b c "BIO - University College Dublin". University College Dublin. Retrieved June 8, 2025.
  2. ^ "Sourav Bhattacharjee - Google Scholar". Google Scholar. Retrieved June 8, 2025.
  3. ^ "Special Issue on Biomedical Imaging in Comparative Anatomy". Journal of Anatomy. 246 (5). 2025. doi:10.1111/joa.v246.5. Retrieved June 8, 2025.
  4. ^ "Oral delivery system". Google Patents. Retrieved June 8, 2025.
  5. ^ Ioannidis, John P.A. (2024). "August 2024 data-update for "Updated science-wide author databases of standardized citation indicators"". Elsevier Data Repository. 7. doi:10.17632/btchxktzyw.7. Retrieved June 8, 2025.
  6. ^ "Dr Sourav Bhattacharjee Ranks Among Top 10 Researchers in UCD". UCD School of Veterinary Medicine. Retrieved June 8, 2025.
  7. ^ "Editors - Scientific Reports". Nature Scientific Reports. Retrieved June 8, 2025.
  8. ^ "Are you interested in a career in Anatomy?". The Anatomical Society. Retrieved June 8, 2025.
  9. ^ "Plenary and Keynote Speakers". 2025 NDDTE Conference. Retrieved June 8, 2025.
  10. ^ "Invited Speaker – Dr. Sourav Bhattacharjee". ICBEB 2019 Conference. Retrieved June 8, 2025.
  11. ^ "The promise of nanomedicine research with Sourav Bhattacharjee". Biomedicine Video. 15 December 2020. Retrieved June 8, 2025.
  12. ^ "Clinical applications of nanomedicine research with Sourav Bhattacharjee". Biomedicine Video. 15 December 2020. Retrieved June 8, 2025.
  13. ^ "Guest lectures by Professor Sourav Bhattacharjee from University College Dublin". Estonian University of Life Sciences. Retrieved June 8, 2025.
  14. ^ "Guest Lectures by Prof. Sourav Bhattacharjee". Combivet. Retrieved June 8, 2025.
  15. ^ Ruizendaal, Loes; Bhattacharjee, Sourav; Pournazari, Kamyar; Rosso-Vasic, Milena; de Haan, Laura H. J.; Alink, Gerrit M.; Marcelis, Antonius T. M.; Zuilhof, Han (December 2009). "Synthesis and cytotoxicity of silicon nanoparticles with covalently attached organic monolayers". Nanotoxicology. 3 (4): 339–347. doi:10.3109/17435390903288896. ISSN 1743-5390.
  16. ^ Bhattacharjee, Sourav; de Haan, Laura HJ; Evers, Nynke M.; Jiang, Xue; Marcelis, Antonius TM; Zuilhof, Han; Rietjens, Ivonne MCM; Alink, Gerrit M. (11 September 2010). "Role of surface charge and oxidative stress in cytotoxicity of organic monolayer-coated silicon nanoparticles towards macrophage NR8383 cells". Particle and Fibre Toxicology. 7 (1): 25. Bibcode:2010PFTox...7...25B. doi:10.1186/1743-8977-7-25. ISSN 1743-8977. PMC 2946263. PMID 20831820.
  17. ^ Bhattacharjee, Sourav; Ershov, Dmitry; Fytianos, Kleanthis; van der Gucht, Jasper; Alink, Gerrit M.; Rietjens, Ivonne M. C. M.; Marcelis, Antonius T. M.; Zuilhof, Han (30 April 2012). "Cytotoxicity and cellular uptake of tri-block copolymer nanoparticles with different size and surface characteristics". Particle and Fibre Toxicology. 9 (1): 11. Bibcode:2012PFTox...9...11B. doi:10.1186/1743-8977-9-11. ISSN 1743-8977. PMC 3419642. PMID 22546147.
  18. ^ Bhattacharjee, Sourav; Rietjens, Ivonne M. C. M.; Singh, Mani P.; Atkins, Tonya M.; Purkait, Tapas K.; Xu, Zejing; Regli, Sarah; Shukaliak, Amber; Clark, Rhett J.; Mitchell, Brian S.; Alink, Gerrit M.; Marcelis, Antonius T. M.; Fink, Mark J.; Veinot, Jonathan G. C.; Kauzlarich, Susan M.; Zuilhof, Han (16 May 2013). "Cytotoxicity of surface-functionalized silicon and germanium nanoparticles: the dominant role of surface charges". Nanoscale. 5 (11): 4870–4883. Bibcode:2013Nanos...5.4870B. doi:10.1039/C3NR34266B. ISSN 2040-3372. PMC 3667208. PMID 23619571.
  19. ^ Bhattacharjee, Sourav; and Marcelis, Antonius T. M. (1 February 2013). "Surface charge-specific cytotoxicity and cellular uptake of tri-block copolymer nanoparticles". Nanotoxicology. 7 (1): 71–84. doi:10.3109/17435390.2011.633714. ISSN 1743-5390. PMID 22087472.
  20. ^ Bhattacharjee, Sourav; Ershov, Dmitry; Islam, Mohammed A.; Kämpfer, Angela M.; Maslowska, Katarzyna A.; Gucht, Jasper van der; Alink, Gerrit M.; Marcelis, Antonius T. M.; Zuilhof, Han; Rietjens, Ivonne M. C. M. (24 April 2014). "Role of membrane disturbance and oxidative stress in the mode of action underlying the toxicity of differently charged polystyrene nanoparticles". RSC Advances. 4 (37): 19321–19330. Bibcode:2014RSCAd...419321B. doi:10.1039/C3RA46869K. ISSN 2046-2069.
  21. ^ Bhattacharjee, Sourav (10 August 2016). "DLS and zeta potential – What they are and what they are not?". Journal of Controlled Release. 235: 337–351. doi:10.1016/j.jconrel.2016.06.017. ISSN 0168-3659. PMID 27297779.
  22. ^ Bhattacharjee, Sourav; Mahon, Eugene; Harrison, Sabine M.; McGetrick, Jim; Muniyappa, Mohankumar; Carrington, Stephen D.; Brayden, David J. (1 April 2017). "Nanoparticle passage through porcine jejunal mucus: Microfluidics and rheology". Nanomedicine: Nanotechnology, Biology and Medicine. 13 (3): 863–873. doi:10.1016/j.nano.2016.11.017. ISSN 1549-9634. PMID 27965167.
  23. ^ "Principles of Nanomedicine". WorldCat. Retrieved June 8, 2025.
  24. ^ Midekessa, Getnet; Godakumara, Kasun; Ord, James; Viil, Janeli; Lättekivi, Freddy; Dissanayake, Keerthie; Kopanchuk, Sergei; Rinken, Ago; Andronowska, Aneta; Bhattacharjee, Sourav; Rinken, Toonika; Fazeli, Alireza (14 July 2020). "Zeta Potential of Extracellular Vesicles: Toward Understanding the Attributes that Determine Colloidal Stability". ACS Omega. 5 (27): 16701–16710. doi:10.1021/acsomega.0c01582. PMC 7364712. PMID 32685837.
  25. ^ Bhattacharjee, Sourav (1 January 2021). "Understanding the Burst Release Phenomenon: Toward Designing Effective Nanoparticulate Drug-Delivery Systems". Therapeutic Delivery. 12 (1): 21–36. doi:10.4155/tde-2020-0099. ISSN 2041-5990. PMID 33353422.
  26. ^ Bhattacharjee, Sourav (2023). "An Introduction to Particle Tracking Techniques with Applications in Biomedical Research". Microscopy Techniques for Biomedical Education and Healthcare Practice. Biomedical Visualization. Vol. 2. pp. 103–123. doi:10.1007/978-3-031-36850-9_6. ISBN 978-3-031-36849-3. Retrieved June 8, 2025.
  27. ^ Alqahtani, Abdulsalam; Bhattacharjee, Sourav; Almopti, Abdulrahman; Li, Chunhui; Nabi, Ghulam (1 June 2024). "Radiomics-based machine learning approach for the prediction of grade and stage in upper urinary tract urothelial carcinoma: a step towards virtual biopsy". International Journal of Surgery (London, England). 110 (6): 3258–3268. doi:10.1097/JS9.0000000000001483. ISSN 1743-9159. PMC 11175789. PMID 38704622.
  28. ^ Abdulsalam, Alqahtani; Sourav, Bhattacharjee; Abdulrahman, Almopti; Chunhui, Li; Ghulam, Nabi (January 2024). "Radiomics-Based Computed Tomography Urogram Approach for the Prediction of Survival and Recurrence in Upper Urinary Tract Urothelial Carcinoma". Cancers. 16 (18). doi:10.3390/cancer (inactive 12 June 2025). ISSN 2072-6694.{{cite journal}}: CS1 maint: DOI inactive as of June 2025 (link)
  29. ^ Bhattacharjee, Sourav; Ghosh, Sanjib Kumar (2023). "The Sun Also Rises: Tracing the evolution of humanistic values in anatomy pedagogy and research, including cadaveric acquisition practices". Journal of Anatomy. 243 (6): 1031–1051. doi:10.1111/joa.13938. ISSN 1469-7580. PMC 10641044. PMID 37525506.
  30. ^ Ghosh, Sanjib Kumar; Bhattacharjee, Sourav (2024). "Public human dissection and societal connect of anatomical sciences: A glorious association in the past but ethically forbidden practice at present". Anatomical Sciences Education. 17 (8): 1640–1654. doi:10.1002/ase.2413. ISSN 1935-9780. PMID 38576065.
  31. ^ Bhattacharjee, Sourav; Ceri Davies, D.; Holland, Jane C.; Holmes, Jonathan M.; Kilroy, David; McGonnell, Imelda M.; Reynolds, Alison L. (2022). "On the importance of integrating comparative anatomy and One Health perspectives in anatomy education". Journal of Anatomy. 240 (3): 429–446. doi:10.1111/joa.13570. ISSN 1469-7580. PMC 8819042. PMID 34693516.
  32. ^ "One Health UCD". University College Dublin. Retrieved June 8, 2025.
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Sourav Bhattacharjee publications indexed by Google Scholar

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