User:Kate.Rosenbaum/sandbox

Prep for Peer Review 10/22/2020

Humoral immunity

Lead: slightly edited for grammatical clarity; overall, original provides a solid overview of the page and identifies key vocabulary necessary for comprehension.

Organization: original article includes helpful chart that identifies and defines important terminology, crediting those who coined each discovery. This page definitely appears to be a compilation of other pages, so I plan on spending time connecting the various concepts discussed to correspond better with the overarching topic of humoral immunity.

Balance: the original page feels well-balanced; however, it could benefit from a big-picture analysis of the function of the humoral immune response.

Neutrality: because the topic is very scientific, the page maintains a pretty neutral stance throughout. I did not sense any bias in the original state of the page.

Sources: find source for "endocytosis" and "macrophages." Overall, previous editors have done an excellent job linking relevant sources to key terms and processes mentioned, so minimal revision is required (in my opinion). References section needs revision for accurate citation format.

Overall: this page won't require a significant amount of editing as past editors have clarified most of the terminology and explained the process of immune response in an informative yet relatively easy-to-digest way.

"Alexins, later redefined as "complement" by Paul Ehrlich, were shown to be the soluble components of the innate response that lead to a combination of cellular and humoral immunity. This discovery helped to bridge the features of innate and acquired immunity." restructured sentences for clarification

"Ehrlich, with his colleague Emil von Behring, went on to develop the diphtheria antitoxin, which became the first major success of modern immunotherapy." replaced "friend" to sound less narrative-like

"The discovery of specified compatible antibodies became a major tool in the standardization of immunity and the identification of lingering infections." reworded

"In humoral immune response, the B cells must first mature in the bone marrow and gain B-cell receptors (BCR's) which are then displayed in large number on the cell surface." reworded

"These daughter cells become either plasma cells or memory cells. The memory B cells remain inactive here; later, when these memory B cells encounter the same antigen due to reinfection, they divide and form plasma cells. Daughter cells that become plasma cells produce a large number of antibodies which are released freely into the circulatory system." reworded and added comma

"This will either interfere with the chemical interaction between host and foreign cells, lead to the formation of bridges between antigenic sites and hinder their proper functioning, or their presence will attract macrophages to attack and phagocytose them." reworded; find source for "macrophages"

"Antibodies, in particular the IgG1 class, can also "fix" complements." added "s"