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TCA CYCLEKREBS CYCLE Definition: is a series of enzyme catalyzed cyclical reactions in mitochondria by which acetyl - CoA is completely oxidized to CO2 with the production of energy in the form of ATP, NADH & FADH2. This cycle is also known as citric acid cycle as well as Kreb’s cycle. TCA cycle is the final common metabolic pathway for the oxidation of carbohydrate, lipid & protein because glucose, fatty acid & amino acids are metabolized to acetyl - CoA. Acetyl - CoA is the active form of acetate.