VA012

VA012
Identifiers
	IUPAC name N-[(1-benzylindol-3-yl)methyl]pyridin-3-amine;
CAS Number	885898-58-8;
PubChem CID	1497577;
ChemSpider	1234576;
ChEMBL	ChEMBL4095079;
Chemical and physical data
Formula	C21H19N3
Molar mass	313.404 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES C1=CC=C(C=C1)CN2C=C(C3=CC=CC=C32)CNC4=CN=CC=C4;
	InChI InChI=1S/C21H19N3/c1-2-7-17(8-3-1)15-24-16-18(20-10-4-5-11-21(20)24)13-23-19-9-6-12-22-14-19/h1-12,14,16,23H,13,15H2; Key:FXRHZHGEENHPFI-UHFFFAOYSA-N;

VA012 is an experimental drug from the indole family, which is acts as a selective positive allosteric modulator of the 5-HT_2C receptor. It has anorectic effects in animal studies with an improved side effect profile compared to directly acting 5-HT_2C agonists such as lorcaserin.^[1]

References

^ García-Cárceles J, Decara JM, Vázquez-Villa H, Rodríguez R, Codesido E, Cruces J, et al. (December 2017). "A Positive Allosteric Modulator of the Serotonin 5-HT2C Receptor for Obesity". Journal of Medicinal Chemistry. 60 (23): 9575–9584. doi:10.1021/acs.jmedchem.7b00994. PMID 29116785.

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[Garcia-Carceles_2017-1] García-Cárceles J, Decara JM, Vázquez-Villa H, Rodríguez R, Codesido E, Cruces J, et al. (December 2017). "A Positive Allosteric Modulator of the Serotonin 5-HT2C Receptor for Obesity". Journal of Medicinal Chemistry. 60 (23): 9575–9584. doi:10.1021/acs.jmedchem.7b00994. PMID 29116785.

[1]

See also

References