Jump to content

Benanserin

Add links
From Wikipedia, the free encyclopedia
(Redirected from MC4788)
Benanserin
Clinical data
Other namesBenanserine; MC-4788; Sq-4788; Benzyl antiserotonin; Benzylantiserotonin; BAS; Serotonin benzyl analogue; Wooley's antiserotonin; 1-Benzyl-2-methyl-5-methoxytryptamine
Routes of
administration		Oral, intravenous injection[1]
Drug classSerotonin receptor antagonist; Tranquilizer
Identifiers
  • 2-(1-benzyl-5-methoxy-2-methylindol-3-yl)ethanamine
CAS Number
PubChem CID
ChemSpider
UNII
ChEMBL
Chemical and physical data
FormulaC19H22N2O
Molar mass294.398 g·mol−1
3D model (JSmol)
  • CC1=C(C2=C(N1CC3=CC=CC=C3)C=CC(=C2)OC)CCN
  • InChI=1S/C19H22N2O/c1-14-17(10-11-20)18-12-16(22-2)8-9-19(18)21(14)13-15-6-4-3-5-7-15/h3-9,12H,10-11,13,20H2,1-2H3
  • Key:RPSOLZRELOLSFM-UHFFFAOYSA-N

Benanserin, also known as benzyl antiserotonin (BAS), by its developmental code name MC-4788 or Sq-4788, and by its chemical name 1-benzyl-2-methyl-5-methoxytryptamine, is a serotonin receptor antagonist and described tranquilizer of the tryptamine and 5-methoxytryptamine families.[2][1][3][4] It is the derivative of 5-methoxytryptamine with a benzyl group at the 1 position and a methyl group at the 2 position.[2][3] The drug is said to be active in humans at a dose of 10 to 35 mg orally or intravenously.[1] In contrast to certain other serotonin receptor antagonists like chlorpromazine, benanserin does not antagonize the subjective effects of the serotonergic psychedelic LSD.[4] It was first described in the scientific literature by at least 1955 and was one of the first serotonin antagonists.[2][5]

See also

[edit]

References

[edit]
  1. ^ a b c Usdin, Earl; Efron, Daniel H. (1972). Psychotropic Drugs and Related Compounds. National Institute of Mental Health. Retrieved 28 June 2025.
  2. ^ a b c Elks, J. (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. ISBN 978-1-4757-2085-3. Retrieved 28 June 2025.
  3. ^ a b Negwer, Martin (2001). Organic-chemical Drugs and Their Synonyms: An International Survey. Wiley-VCH. p. 2442. ISBN 978-3-527-30247-5. Retrieved 28 June 2025.
  4. ^ a b Martin, W. R.; Sloan, J. W. (1977). "Pharmacology and Classification of LSD-like Hallucinogens". Drug Addiction II: Amphetamine, Psychotogen, and Marihuana Dependence. Berlin, Heidelberg: Springer Berlin Heidelberg. pp. 305–368. doi:10.1007/978-3-642-66709-1_3. ISBN 978-3-642-66711-4.
  5. ^ Shaw, Elliott (1955). "The Synthesis of Tryptamines Related to Serotonin". Journal of the American Chemical Society. 77 (16): 4319–4324. doi:10.1021/ja01621a042. ISSN 0002-7863. Retrieved 28 June 2025.
Stub icon

This psychoactive drug-related article is a stub. You can help Wikipedia by expanding it.

Retrieved from "https://en.wikipedia.org/w/index.php?title=Benanserin&oldid=1297770895"