Upjohn

The Upjohn Company
The Upjohn Company
公司類型	公司
公司結局	與Pharmacia合併為Pharmacia & Upjohn
後繼機構	Pharmacia & Upjohn; 暉致（Viatris）
成立	1886年
結束	1995年，30年前
總部	美國密西根州波蒂奇
產業	製藥產業

Upjohn是一家美國製藥公司，1886年由威廉·E·厄普約翰在密西根州黑斯廷斯成立^[1]，1995年與Pharmacia合併為Pharmacia & Upjohn，現為輝瑞公司所有。

歷史

1976年，公司的三位科學家開發了Upjohn雙羥基化反應^[2]。

產品

名稱	CAS號	分子式
U-47109	67579-13-9	C 15H 20Cl 2N 2O
U-47700	82657-23-6	C 16H 22Cl 2N 2O
溴朵林（U-47931E）	67579-24-2	C₁₅H₂₁BrN₂O
U-48520	67579-11-7	C 16H 23ClN 2O
依氯那明（U-48753）	67450-44-6	C 16H 22Cl 2N 2O
U-48800	2370977-17-4	C 17H 24Cl 2N 2O
U-49900	67579-76-4	C 18H 26Cl 2N 2O
U-50211	98587-47-4	C 16H 24N 2O 2
U-50488	67198-13-4	C 19H 26Cl 2N 2O
U-51574	PubChem CID：44269303	C 17H 24Cl 2N 2O
螺朵林（英語：Spiradoline）（U-62066）	87151-85-7	C 22H 30Cl 2N 2O 2
U-69593	96744-75-1	C 22H 32N 2O 2
U-77891	119878-31-8	C 18H 24Br 2N 2O
U-101958	170856-57-2	C 21H 29N 3O

參考文獻

^ Lohrstorfer, Martha; Larson, Catherine. William E. Upjohn: Person of the Century 1853 - 1932. Kalamazoo Public Library. 2002 [December 24, 2024]. （原始內容存檔於May 17, 2008）. Known by his contemporaries as a dreamer and a tinkerer, Dr. Upjohn saw a need to improve the means of administering medicine. Most medicines of the day were in fluid form, and those in pill form were often hard and insoluble. Patients were left to try to digest the bitter medicine, with no guarantee that it would dissolve in their systems effectively. Dr. Upjohn began experimenting with making better pills in the attic of his home. Eventually he invented his "friable" pill. Friable meant that the pill could easily be crushed to a powder. The pill was patented in 1885, and its reputation quickly spread within the medical community, thanks greatly to Dr. Upjohn's marketing strategy. He sent small pine boards to thousands of physicians along with samples of his rival's hard pills, and his own friable pills. He invited doctors to hammer the pills into the boards to see which one would be the most digestible. This tactic was eventually modified, but for the next 60 years, a thumb reducing an Upjohn pill to powder was used as the trademark symbol of his company, the Upjohn Pill and Granule Company, later more widely known to the world as The Upjohn Company.
^ VanRheenen, V.; Kelly, R.C.; Cha, D.Y. An improved catalytic OsO4 oxidation of olefins to -1,2-glycols using tertiary amine oxides as the oxidant. Tetrahedron Letters. 1976-06, 17 (23): 1973–1976. doi:10.1016/S0040-4039(00)78093-2.

外部連結

[1] Lohrstorfer, Martha; Larson, Catherine. William E. Upjohn: Person of the Century 1853 - 1932. Kalamazoo Public Library. 2002 [December 24, 2024]. （原始內容存檔於May 17, 2008）. Known by his contemporaries as a dreamer and a tinkerer, Dr. Upjohn saw a need to improve the means of administering medicine. Most medicines of the day were in fluid form, and those in pill form were often hard and insoluble. Patients were left to try to digest the bitter medicine, with no guarantee that it would dissolve in their systems effectively. Dr. Upjohn began experimenting with making better pills in the attic of his home. Eventually he invented his "friable" pill. Friable meant that the pill could easily be crushed to a powder. The pill was patented in 1885, and its reputation quickly spread within the medical community, thanks greatly to Dr. Upjohn's marketing strategy. He sent small pine boards to thousands of physicians along with samples of his rival's hard pills, and his own friable pills. He invited doctors to hammer the pills into the boards to see which one would be the most digestible. This tactic was eventually modified, but for the next 60 years, a thumb reducing an Upjohn pill to powder was used as the trademark symbol of his company, the Upjohn Pill and Granule Company, later more widely known to the world as The Upjohn Company.

[2] VanRheenen, V.; Kelly, R.C.; Cha, D.Y. An improved catalytic OsO4 oxidation of olefins to -1,2-glycols using tertiary amine oxides as the oxidant. Tetrahedron Letters. 1976-06, 17 (23): 1973–1976. doi:10.1016/S0040-4039(00)78093-2.

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